Activation of TNF‐α/NF‐κB axis enhances CRL4BDCAF 11 E3 ligase activity and regulates cell cycle progression in human osteosarcoma cells
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DOI: 10.1002/1878-0261.12176
Abstract: Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11… read more here.
Keywords: ligase; osteosarcoma; tnf axis; osteosarcoma cells ... See more keywords
TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
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DOI: 10.1016/j.tranon.2020.100950
Abstract: Highlights • Elevated soluble TNFR1 levels are predictive of liver toxicity among patients receiving radiation.• Soluble TNFR1 levels do not independently predict liver toxicity when included in models with ALBI and mean liver dose.• Data… read more here.
Keywords: tnfr1; tnfr1 tnf; tnf axis; radiation ... See more keywords
Immunosuppressant Therapies in COVID-19: Is the TNF Axis an Alternative?
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DOI: 10.3390/ph15050616
Abstract: The study of cytokine storm in COVID-19 has been having different edges in accordance with the knowledge of the disease. Various cytokines have been the focus, especially to define specific treatments; however, there are no… read more here.
Keywords: immunosuppressant therapies; therapies covid; covid tnf; axis alternative ... See more keywords