γδ T Cells Contribute to the Outcome of Murine Fulminant Viral Hepatitis via Effector Cytokines TNF-α and IFN-γ
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DOI: 10.1007/s11596-018-1926-x
Abstract: SummaryThe mechanisms involved in virus-induced severe hepatitis have not been fully elucidated. In this study, we investigated the role of gamma delta T cell receptors (γδ) T cells in the pathogenesis of fulminant viral hepatitis… read more here.
Keywords: cytokines tnf; hepatitis; fulminant viral; effector cytokines ... See more keywords
TNFα and IFNγ cooperate for efficient pro- to anti-inflammatory transition of macrophages during muscle regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209976119
Abstract: Significance The release of cytokines from various immune cells is known to be essential for successful muscle regeneration. However, the precise cellular origin of some of these cytokines and how they influence each other are… read more here.
Keywords: regeneration; muscle regeneration; tnf ifn; transition macrophages ... See more keywords
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1
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DOI: 10.1111/acel.13646
Abstract: Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors for developing severe complications from COVID‐19 infection. The pathogenesis of COVID‐19‐related cytokine storm, tissue damage, and fibrosis may be interconnected… read more here.
Keywords: tnf ifn; jak; expression; senescence ... See more keywords
PO-291 The disbalance of the basic cytokines of the immune system in patients with ovarian cancer on the background of immunotherapy
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DOI: 10.1136/esmoopen-2018-eacr25.805
Abstract: Introduction The violation of the balance in the cytokine system is considered as an important mechanism for the development of cancer processes and ovarian cancer (OC). According to scientific confirmation, in the process of neogenesis… read more here.
Keywords: group patients; group; tnf ifn; ovarian cancer ... See more keywords
Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-00938-1
Abstract: Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothesis… read more here.
Keywords: demyelination; tnf ifn; inflammatory cytokines; expression ... See more keywords
Gene expression of pro-inflammatory (IL-8, IL-18, TNF-α, and IFN-γ) and anti-inflammatory (IL-10) cytokines in the duodenum of broiler chickens exposed to lipopolysaccharides from Escherichia coli and Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary World"
DOI: 10.14202/vetworld.2023.564-570
Abstract: Background and Aim: Intestinal infections are associated with Gram-negative bacteria like Escherichia coli. When eliminated by treatments during replication, E. coli release lipopolysaccharides (LPS) that can activate the intestinal immune system and increase the expression… read more here.
Keywords: tnf ifn; pro inflammatory; expression; anti inflammatory ... See more keywords
Pluripotent stem cells are insensitive to the cytotoxicity of TNFα and IFNγ.
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DOI: 10.1530/rep-20-0215
Abstract: Recent studies have demonstrated that embryonic stem cells (ESCs) have an underdeveloped innate immune system, but the biological implications of this finding are poorly understood. In this study, we compared the responses of mouse ESCs… read more here.
Keywords: ifn; tnf ifn; mesc fbs; cytotoxicity ... See more keywords
Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.937982
Abstract: In this work, we sought to investigate the direct effects of proinflammatory mediators on lymphatic endothelial cell (LEC) capillaries and whether they might induce regression. Our laboratory has developed novel in-vitro, serum-free, lymphatic tubulogenesis assay… read more here.
Keywords: tnf ifn; regression; proinflammatory mediators; tube ... See more keywords
Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-α/IFN-γ-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2/HO-1 and NF-κB/MAPK Pathways
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DOI: 10.3390/antiox11081429
Abstract: Sargassum horneri is a well-known edible brown alga that is widely abundant in the sea near China, Korea, and Japan and has a wide range of bioactive compounds. Fucosterol (FST), which is a renowned secondary… read more here.
Keywords: tnf ifn; stimulated human; ifn stimulated; brown alga ... See more keywords
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels
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DOI: 10.3390/biology10030205
Abstract: Simple Summary The influence of Short-chain fatty acids (SCFAs) on barrier function under pathological conditions has not been assessed, and the regulation of the tight junction (TJ) proteins by SCFAs under pathological conditions has not… read more here.
Keywords: barrier; claudin; intestinal barrier; barrier dysfunction ... See more keywords
Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23179863
Abstract: Boswellic acids, triterpenoids derived from the genus Boswellia (Burseraceae), are known for their anti-inflammatory and anti-tumor efficacy. Atopic dermatitis is a chronic, non-infectious inflammatory skin disease. However, the effects of α-boswellic acid on atopic dermatitis… read more here.
Keywords: balb mice; tnf ifn; boswellic acid; atopic dermatitis ... See more keywords