Paradoxical Psoriasiform Eruptions in Children Receiving Tumor Necrosis Factor α Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2023.0549
Abstract: Importance Tumor necrosis factor α (TNF) inhibitor-induced psoriasiform eruption is well recognized in adults, but few reports document this paradoxical effect in children. Objective To characterize the clinical features and the clinical time course of… read more here.
Keywords: tnf inhibitor; psoriasiform eruptions; inhibitor; eruption ... See more keywords
PBMC CDC42 reveals the disease activity and treatment efficacy of TNF inhibitor in patients with ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24267
Abstract: Cell division cycle 42 (CDC42) regulates the polarization of M2 macrophage and maintains the T cell homeostasis, to participate in multiple autoimmune diseases, while its clinical involvement in ankylosing spondylitis (AS) remains unclear. Hence, the… read more here.
Keywords: tnf inhibitor; treatment; cdc42; ankylosing spondylitis ... See more keywords
Decrease of MiR-31 induced by TNF-α inhibitor activates SATB2/RUNX2 pathway and promotes osteogenic differentiation in ethanol-induced osteonecrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of cellular physiology"
DOI: 10.1002/jcp.27210
Abstract: PURPOSE Suppressed osteogenic differentiation is considered a main cause of ethanol-induced osteonecrosis. Tumor necrosis factor α (TNF-α) and miR-31 have been reported to be involved in the osteogenic induction. This study aimed to explore a… read more here.
Keywords: tnf inhibitor; differentiation; osteogenic differentiation; ethanol induced ... See more keywords
Modulation of TNFR 1-triggered two opposing signals for inflammation and apoptosis via RIPK 1 disruption by geldanamycin in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05579-w
Abstract: To evaluate the ability of geldanamycin to modulate two opposing TNFα/TNFR1-triggered signals for inflammation and cell death. The effects of geldanamycin on TNFα-induced proinflammatory cytokine production, apoptosis, NF-κB activation, caspase activation, and necroptosis in a… read more here.
Keywords: tnf; apoptosis; two opposing; tnf inhibitor ... See more keywords
Paradoxical gastrointestinal reactions in patients taking tumor necrosis factor inhibitors: a rare event that broadens the histologic spectrum of medication-associated injury.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2018.11.003
Abstract: Tumor necrosis factor (TNF) inhibitors are widely used in the therapy of certain autoimmune disorders. Paradoxical immunologic reactions manifesting as new-onset autoimmune disease or exacerbation of the underlying condition have been reported in association with… read more here.
Keywords: patients taking; tnf inhibitor; tumor necrosis; tnf inhibitors ... See more keywords
Switching tumor necrosis factor inhibitors in the treatment of axial spondyloarthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2017.04.005
Abstract: OBJECTIVE To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA). METHODS PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching,… read more here.
Keywords: tnf inhibitor; necrosis factor; tumor necrosis;
Successful cessation of tumor necrosis factor inhibitor treatment in rheumatoid arthritis patients and potential predictors for early flare: An observational study in routine clinical care
Sign Up to like & getrecommendations! Published in 2019 at "Modern Rheumatology"
DOI: 10.1080/14397595.2019.1702253
Abstract: Abstract Objectives: To investigate the prevalence and the consequence of tumor necrosis factor inhibitor (TNFi) cessation after clinical improvement in rheumatoid arthritis (RA) patients in clinical practice and predictors of flare after TNFi cessation. Methods:… read more here.
Keywords: inhibitor; methotrexate; tnf inhibitor; tnfi cessation ... See more keywords
Retention rate and effectiveness of secukinumab vs TNF inhibitor in ankylosing spondylitis patients with prior TNF inhibitor exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab245
Abstract: OBJECTIVES The choice of second-line biologics for ankylosing spondylitis (AS) patients previously treated with a tumour necrosis factor inhibitor (TNFi) remains unclear. Here, we compared drug retention and clinical efficacy between AS patients who switched… read more here.
Keywords: tnfi; inhibitor; clinical efficacy; tnf inhibitor ... See more keywords
No increased risk of herpes zoster in TNF inhibitor and non‐TNF inhibitor users with rheumatoid arthritis: epidemiological study using the Japanese health insurance database
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.13300
Abstract: It is controversial whether the use of biological disease‐modifying antirheumatic drugs (DMARDs) increases the risk of herpes zoster (HZ). We aimed to evaluate the risks of HZ in tumor necrosis factor inhibitor (TNFI) and non‐TNFI… read more here.
Keywords: inhibitor; herpes zoster; tnf inhibitor; rheumatoid arthritis ... See more keywords
Adnexotropic and granulomatous mycosis fungoides following TNF-α inhibitor treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cutaneous pathology"
DOI: 10.1111/cup.14441
Abstract: Recent publications have documented an increased prevalence of cutaneous T-cell lymphoma (CTCL) in patients undergoing tumor necrosis factor alpha (TNF-α) inhibitor therapy. Herein, we present an uncommon manifestation of mycosis fungoides (MF) with unique pathological… read more here.
Keywords: tnf inhibitor; cell; mycosis fungoides; treatment ... See more keywords
A tissue atlas of ulcerative colitis revealing evidence of sex-dependent differences in disease-driving inflammatory cell types and resistance to TNF inhibitor therapy
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add1166
Abstract: Although literature suggests that resistance to TNF inhibitor (TNFi) therapy in patients with ulcerative colitis (UC) is partially linked to immune cell populations in the inflamed region, there is still substantial uncertainty underlying the relevant… read more here.
Keywords: tnf inhibitor; cell; cell types; resistance tnf ... See more keywords