Regulatory Safety Learning Driven by the Mechanism of Action: The Case of TNF‐α Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2127
Abstract: The summary of product characteristics (SmPCs) is an important information source that includes the adverse drug reactions (ADRs) associated with the drug. Drugs with the same mechanism of action are expected to have a similar… read more here.
Keywords: mechanism action; safety; tnf; tnf inhibitors ... See more keywords
Serum uric acid increases in patients with systemic autoimmune rheumatic diseases after 3 months of treatment with TNF inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Rheumatology International"
DOI: 10.1007/s00296-019-04394-6
Abstract: In patients with gout, the serum uric acid (SUA) is usually lower during acute gouty attacks than during intercritical periods. It has been suggested that systemic inflammatory response can cause this phenomenon. The objective is… read more here.
Keywords: uric acid; tnf; treatment; serum uric ... See more keywords
Clonal expansion of large granular lymphocytes in patients with spondyloarthritis and psoriatic arthritis treated with TNFα inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04872-w
Abstract: To determine the prevalence of clonal T-large granular lymphocyte (T-LGL) cells in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to define possible risk factors for this condition. We present a cross-sectional analysis with… read more here.
Keywords: psoriatic arthritis; patients spondyloarthritis; lgl; large granular ... See more keywords
Is Takayasu arteritis the result of a Mycobacterium tuberculosis infection? The use of TNF inhibitors may be the proof-of-concept to demonstrate that this association is epiphenomenal
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05045-z
Abstract: Although the association between Takayasu arteritis (TA) and latent or active Mycobacterium tuberculosis infection has been suggested for a long time, studies conducted in recent years are challenging this notion. Until recently, the possibility of… read more here.
Keywords: use; association; tnf inhibitors; mycobacterium tuberculosis ... See more keywords
TNF Inhibitors for Psoriasis and Psoriatic Arthritis
Sign Up to like & getrecommendations! Published in 2017 at "Current Dermatology Reports"
DOI: 10.1007/s13671-017-0174-9
Abstract: Purpose of ReviewA growing body of research highlights the use of TNF inhibitors in the treatment of psoriasis and psoriatic arthritis. We aim to review the literature, compile psoriasis efficacy data for TNF inhibitors, and… read more here.
Keywords: psoriasis; psoriatic arthritis; psoriasis psoriatic; tnf inhibitors ... See more keywords
Biologic drugs in the treatment of polyarteritis nodosa and deficit of adenosine deaminase 2: A narrative review.
Sign Up to like & getrecommendations! Published in 2021 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2021.102784
Abstract: Polyarteritis nodosa (PAN) is a medium vessels vasculitis variously involving different organs and systems, sometimes with an aggressive course, leading to death or disability in a significant number of cases. First-line treatment usually relies on… read more here.
Keywords: polyarteritis nodosa; deficit adenosine; biologic drugs; treatment ... See more keywords
Real-world Effectiveness of Biologic Disease-modifying Antirheumatic Drugs for the Treatment of Rheumatoid Arthritis After Etanercept Discontinuation in the United Kingdom, France, and Germany.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2017.06.009
Abstract: PURPOSE The purpose of this study was to assess the real-world effectiveness of patients with rheumatoid arthritis (RA) who discontinued etanercept treatment and subsequently received another tumor necrosis factor α (TNF-α) inhibitor or a non-TNF-α… read more here.
Keywords: tnf biologics; tnf; united kingdom; treatment ... See more keywords
Paradoxical gastrointestinal reactions in patients taking tumor necrosis factor inhibitors: a rare event that broadens the histologic spectrum of medication-associated injury.
Sign Up to like & getrecommendations! Published in 2019 at "Human pathology"
DOI: 10.1016/j.humpath.2018.11.003
Abstract: Tumor necrosis factor (TNF) inhibitors are widely used in the therapy of certain autoimmune disorders. Paradoxical immunologic reactions manifesting as new-onset autoimmune disease or exacerbation of the underlying condition have been reported in association with… read more here.
Keywords: patients taking; tnf inhibitor; tumor necrosis; tnf inhibitors ... See more keywords
Spondyloarthropathies: TNF inhibitors and structural damage in ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Rheumatology"
DOI: 10.1038/nrrheum.2017.197
Abstract: Whether TNF inhibitors prevent structural damage in ankylosing spondylitis remains a controversial topic, as three prospective trials failed to show any evidence to support this notion. However, data are accumulating from retrospective analyses of well-characterized… read more here.
Keywords: structural damage; damage ankylosing; tnf inhibitors; ankylosing spondylitis ... See more keywords
Update upon the infection risk in patients receiving TNF alpha inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2019.1577817
Abstract: ABSTRACT Introduction: TNF-α inhibitors can be administered either as monotherapy or in combination with other anti-inflammatory drugs or DMARDs in the treatment of chronic immune-mediated diseases. Areas covered: Patients receiving TNF-α inhibitors are at high… read more here.
Keywords: risk; update upon; infection; patients receiving ... See more keywords
Safety of the JAK and TNF inhibitors in rheumatoid arthritis: real world data from the Hong Kong Biologics Registry.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead198
Abstract: OBJECTIVES To compare the incidence of major adverse cardiovascular events (MACEs), cancer and infective complications in rheumatoid arthritis (RA) patients using the JAK (JAKis) and TNF inhibitors (TNFis). METHOD A retrospective analysis of data from… read more here.
Keywords: hong kong; tnf inhibitors; rheumatoid arthritis; patient years ... See more keywords