Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25424
Abstract: The cytokine tumor necrosis factor (TNF) is involved in the regulation of physiological and pathophysiological processes in the central nervous system. In previous work, we showed that mice lacking constitutive levels of TNF exhibit a… read more here.
Keywords: tnf receptor; tnf; granule; granule cells ... See more keywords
Analysis of FcγR-Dependent Agonism of Antibodies Specific for Receptors of the Tumor Necrosis Factor (TNF) Receptor Superfamily (TNFRSF).
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1130-2_6
Abstract: In vivo research of the last decade revealed that the anchoring of antitumor necrosis factor (TNF) receptor superfamily (TNFRSF) receptor antibodies to cell-expressed Fcγ receptors (FcγR) can be of decisive relevance for their receptor-stimulatory activity.… read more here.
Keywords: superfamily tnfrsf; receptor superfamily; factor tnf; receptor ... See more keywords
Computational explorations to gain insight into the structural features of TNF-α receptor I inhibitors
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1440-x
Abstract: TNF-α is a crucial cytokine in the process of inflammatory diseases. The adverse effect of TNF-α is mostly mediated by interaction of TNF-α with TNF-α receptor type I (TNFR1); therefore, discovery of molecules which can… read more here.
Keywords: computational explorations; structural features; receptor; tnf receptor ... See more keywords
TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.186
Abstract: Oncostatin M (OSM) is involved in pathogenesis of several human inflammatory diseases including lung inflammation and fibrosis. Although accumulating evidence indicates that OSM mediates lung inflammation, the precise mechanism for OSM on lung inflammation still… read more here.
Keywords: tnf receptor; inflammation; lung inflammation; receptor associated ... See more keywords
Identification and characterization of a TNF receptor-associated factor in Dugesia japonica.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.09.038
Abstract: The tumor necrosis factor (TNF) superfamily consists of a wide variety of inflammatory cytokine, including cell-bound and secreted proteins. These TNFs function through binding and activation of the TNF receptors for modulating TNF-associated intracellular signals.… read more here.
Keywords: tnf; dugesia japonica; factor; tnf receptor ... See more keywords
Functional Detection of TNF Receptor Family Members by Affinity-Labeled Ligands
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DOI: 10.1038/s41598-017-06343-4
Abstract: Aberrant expression of TNF family of cytokines has been linked to human diseases, and biologics targeting their signaling have become the best selling drugs globally. However, functional detection with labeled ligands for accurate detection of… read more here.
Keywords: labeled ligands; functional detection; family; receptor ... See more keywords
Monovalent TNF receptor 1-selective antibody with improved affinity and neutralizing activity
Sign Up to like & getrecommendations! Published in 2019 at "mAbs"
DOI: 10.1080/19420862.2018.1524664
Abstract: ABSTRACT Selective inhibition of tumor necrosis factor (TNF) signaling through the proinflammatory axis of TNF-receptor 1 (TNFR1) while leaving pro-survival and regeneration-promoting signals via TNFR2 unaffected is a promising strategy to circumvent limitations of complete… read more here.
Keywords: tnf; antibody; inhibition; tnf receptor ... See more keywords
TNF receptor signalling in autoinflammatory diseases.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz024
Abstract: Autoinflammatory syndromes are a group of disorders characterised by recurring episodes of inflammation as a result of specific defects in the innate immune system. Patients with autoinflammatory disease present with recurrent outbreaks of chronic systemic… read more here.
Keywords: receptor signalling; signalling autoinflammatory; tnf receptor; autoinflammatory diseases ... See more keywords
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abm4552
Abstract: GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors into a high-order array. Immunotherapeutic… read more here.
Keywords: activation; therapeutic antibody; antibody; tnf receptor ... See more keywords
A novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1136/annrheumdis-2022-eular.1098
Abstract: OBJECTIVE We describe a family with a novel mutation in the TNF Receptor Superfamily Member 1A gene (TNFRSF1A) causing tumour necrosis factor receptor-associated periodic syndrome (TRAPS) with renal AA-amyloidosis. METHODS Case series of affected family… read more here.
Keywords: tnf receptor; associated periodic; treatment; mutation ... See more keywords
Abstract 429: Tnf Receptor-1 Dictates Life/death Decisions of Auto-reactive T-lymphocytes During Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.429
Abstract: Ischemic heart failure (HF) results in the activation of self-reactive CD4+ T-lymphocytes against unknown cardiac antigens. The mechanisms that mediate the survival of self-reactive T-cells during ischemic HF are not known. TNF mediated NF-kB signaling… read more here.
Keywords: tnfr1; tnf receptor; tnfr1 cells; heart failure ... See more keywords