Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages
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DOI: 10.1159/000480217
Abstract: Background/Aims: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid… read more here.
Keywords: histone; tumor necrosis; tnf release; necrosis factor ... See more keywords
Toll-Like Receptor 2 Modulates Pulmonary Inflammation and TNF-α Release Mediated by Mycoplasma pneumoniae
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DOI: 10.3389/fcimb.2022.824027
Abstract: Objectives To investigate the roles that Toll-like receptors (TLRs) play in lung inflammation mediated by Mycoplasma pneumoniae (MP). Methods The changes in TLRs and tumor necrosis factor alpha (TNF-α) in peripheral blood of children with… read more here.
Keywords: inflammation; toll like; tnf; mediated mycoplasma ... See more keywords
Tumor necrosis factor is a necroptosis-associated alarmin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1074440
Abstract: Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis leads to strong inflammatory responses, little is known about the identity… read more here.
Keywords: cell death; necroptosis; cell; lytic cell ... See more keywords