Blocking TNF signaling may save lives in COVID-19 infection
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology Reports"
DOI: 10.1007/s11033-022-07166-x
Abstract: Global vaccination effort and better understanding of treatment strategies provided a ray of hope for improvement in COVID-19 pandemic, however, in many countries, the disease continues to collect its death toll. The major pathogenic mechanism… read more here.
Keywords: may save; save lives; tnf signaling; lives covid ... See more keywords
Salmonella enteritidis Hcp distribute in the cytoplasm and regulate TNF signaling pathway in BHK-21 cells
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-02296-0
Abstract: Hemolysin-coregulated protein (Hcp) of Salmonella enteritidis is known to be a structural and effector protein of the T6SS, but little is known about the role of Hcp in host cells. In this study, Hcp was… read more here.
Keywords: tnf signaling; salmonella enteritidis; hcp; signaling pathway ... See more keywords
Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00948-w
Abstract: Go-sha-jinki-Gan (GJG) is a traditional Japanese herbal medicine. In clinical practice, GJG is effective against neuropathic pain and hypersensitivity induced by chemotherapy or diabetes. In our previous study using a chronic constriction injury mouse model,… read more here.
Keywords: p38 tnf; tnf; tnf signaling; nervous system ... See more keywords
Intracellular regulation of TNF activity in health and disease.
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2016.08.035
Abstract: Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation… read more here.
Keywords: tnf; tnf signaling; regulation tnf; health ... See more keywords
Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0131-z
Abstract: Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow… read more here.
Keywords: tnf; tnfr2; tnf signaling; myelofibrosis ... See more keywords
Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114406119
Abstract: Significance GBS and CIDP are autoimmune disorders of the PNS that can be debilitating and even life threatening. Current therapies, which include corticosteroids and intravenous gammaglobulin, have poorly defined mechanisms of action and are ineffective… read more here.
Keywords: tnf signaling; cell; tnf; autoimmunity ... See more keywords
TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-16-0329
Abstract: Elucidation of TNF-directed mechanisms for cell death induction and maintenance of tumor growth has revealed a role for receptor-interacting protein kinases 1 and 3 (RIPK1/RIP1 and RIPK3/RIP3), components of the necrosome complex, as determinants of… read more here.
Keywords: death; tnf; tnf signaling; colon ... See more keywords
The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000494602
Abstract: Background/Aims: This study is aimed at identification of miR-195-5p/MMP14 expression in cervical cancer (CC) and their roles on cell proliferation and invasion profile of CC cells through TNF signaling pathway in CC. Methods: Microarray analysis,… read more here.
Keywords: mir 195; tnf signaling; analysis; signaling pathway ... See more keywords
Pulsed Electromagnetic Field Attenuates Osteoarthritis Progression in a Murine Destabilization-Induced Model through Inhibition of TNF-α and IL-6 Signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Cartilage"
DOI: 10.1177/19476035211049561
Abstract: OBJECTIVE To investigate the anti-inflammatory effects and mechanisms of pulsed electromagnetic field (PEMF) in the treatment of osteoarthritis (OA) in the destabilization of the medial meniscus (DMM) mice. DESIGN Ten-week-old male wild-type (WT), interleukin (IL)-6-/-… read more here.
Keywords: pemf; electromagnetic field; tnf signaling; mice ... See more keywords
LPS-TLR4/MD-2–TNF-α signaling mediates alcohol-induced liver fibrosis in rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Toxicologic Pathology"
DOI: 10.1293/tox.2021-0018
Abstract: Liver fibrosis results from liver inflammation and progresses to liver cirrhosis or liver cancer. It is known that nonalcoholic liver disease is mediated by the Toll-like receptor 4 (TLR4)/myeloid differentiation factor-2 (MD-2)–tumor necrosis factor-alpha (TNF-α)… read more here.
Keywords: tnf signaling; liver fibrosis; tlr4 tnf;
TNF Signaling Impacts Glucagon-Like Peptide-1 Expression and Secretion.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0129
Abstract: Numerous studies have implicated tumor necrosis factor α (TNFα) in the pathogenesis of type 2 diabetes. However, the role of its primary receptor, TNF receptor 1 (TNFR1), in homeostatic regulation of glucose metabolism is still… read more here.
Keywords: secretion; tnf; tnfr1 tnf; tnf signaling ... See more keywords