Towards the development of a human in vitro model of the blood-brain barrier for virus-associated acute encephalopathy: assessment of the time- and concentration-dependent effects of TNF-α on paracellular tightness.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental brain research"
DOI: 10.1007/s00221-020-05985-7
Abstract: The pathogenesis of virus-associated acute encephalopathy (VAE) involves brain edema caused by disruption of the blood-brain barrier (BBB). We aimed to develop an in vitro VAE model using an in vitro BBB model, to evaluate… read more here.
Keywords: tnf treatment; model; virus associated; concentration ... See more keywords
Replying to the letter entitled “Could anti-TNF treatment have affected HRV and HRT results?”
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Rheumatology"
DOI: 10.1007/s10067-020-05447-z
Abstract: We thank Dr. Yalım and his colleagues for their interest and comments about our study which demonstrated that the cardiac autonomic nervous systemwas affected using 12-lead electrocardiography and Holter monitoring in patients with ankylosing spondylitis… read more here.
Keywords: autonomic nervous; cardiac autonomic; tnf treatment; anti tnf ... See more keywords
Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes
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DOI: 10.1016/j.scr.2021.102218
Abstract: Proinflammatory molecule tumor necrosis factor alpha (TNF-α) is predominantly elevated in cytokine storm as well as worsening cardiac function. Here we model the molecular and functional effects of TNF-α in cardiomyocytes (CMs) derived from human… read more here.
Keywords: functional molecular; tnf treatment; treatment; molecular effects ... See more keywords
Effect of Anti-TNF Treatment on Mooren’s Ulcer: A Case Series and Review of the Literature
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DOI: 10.1080/09273948.2021.2023581
Abstract: ABSTRACT We present our experience with five patients treated with anti-tumor necrosis factor alpha (TNF-α) agents who were unresponsive to conventional treatment. Additionally, we summarize the current experience with biological disease-modifying anti-rheumatic drugs (bDMARDs) in… read more here.
Keywords: mooren ulcer; anti tnf; case series; treatment ... See more keywords
P674 Definition of a microbial signature as a predictor of anti-TNFα treatment response
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DOI: 10.1093/ecco-jcc/jjab076.794
Abstract: Crohn’s disease (CD) and ulcerative colitis (UC) evolve with alternate outbreaks and remissions of variable duration. Tumour necrosis factor α antagonists (anti-TNFα) have enhanced the treatment of patients with inflammatory bowel disease (IBD), improving the… read more here.
Keywords: response; tnf treatment; microbial signature; treatment ... See more keywords
The Citrullinated and MMP-degraded Vimentin Biomarker (VICM) Predicts Early Response to Anti-TNFα Treatment in Crohn’s Disease
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DOI: 10.1097/mcg.0000000000001341
Abstract: Background: In Crohn’s disease (CD), 10% to 40% of patients do not respond to anti-tumor necrosis factor-α (TNFα) treatment. Currently, there are no biomarkers with adequate sensitivity to separate responders from nonresponders at an early… read more here.
Keywords: response; tnf treatment; treatment; anti tnf ... See more keywords
Progression to Anti-TNF Treatment in Very Early Onset Inflammatory Bowel Disease Patients
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DOI: 10.1097/mpg.0000000000003551
Abstract: Objectives: Limited data are currently available regarding anti-tumor necrosis factor (TNF) use and outcomes in very early onset inflammatory bowel disease (VEOIBD) patients. We aimed to assess the long-term outcomes and time to progression to… read more here.
Keywords: progression anti; anti tnf; disease; treatment ... See more keywords
Pharmacogenomics of Anti-TNF Treatment Response Marks a New Era of Tailored Rheumatoid Arthritis Therapy
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DOI: 10.3390/ijms23042366
Abstract: Rheumatoid arthritis (RA) is the most commonly occurring chronic inflammatory arthritis, the exact mechanism of which is not fully understood. Tumor Necrosis Factor (TNF)-targeting drugs has been shown to exert high effectiveness for RA, which… read more here.
Keywords: anti tnf; arthritis; treatment response; response ... See more keywords