The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-020-01902-1
Abstract: Gastric cancer (GC) is the third leading cause of cancer-related death worldwide. Very few therapeutic options are currently available in this neoplasia. The use of 5-Aza-2′-deoxycytidine (5-AZAdC) was approved for the treatment of myelodysplastic syndromes,… read more here.
Keywords: dna; tnfaip3; expression; nrn1 tnfaip3 ... See more keywords
Association of the tandem polymorphisms (rs148314165, rs200820567) in TNFAIP3 with chronic hepatitis B virus infection in Chinese Han population
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DOI: 10.1186/s12985-017-0814-5
Abstract: BackgroundChronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene, is complicated in HBV infection and liver injury. The… read more here.
Keywords: infection; tnfaip3; hepatitis virus; hbv infection ... See more keywords
Genetic Polymorphisms in Genes Involved in the Type I Interferon System (IFIH1/MDA-5, TNFAIP3/A20, and STAT4): Association with SLE Risk in Egyptian Children and Adolescents
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s309008
Abstract: Purpose Systemic lupus erythematosus (SLE) is a multifactorial autoimmune inflammatory disease that is influenced by both genetic and environmental factors and associated with dysregulation of type I interferon (INF) response. This study aimed to investigate… read more here.
Keywords: sle risk; tnfaip3; stat4; children adolescents ... See more keywords
Systemic lupus erythematosus variants modulate the function of an enhancer upstream of TNFAIP3
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DOI: 10.3389/fgene.2022.1011965
Abstract: TNFAIP3/A20 is a prominent autoimmune disease risk locus that is correlated with hypomorphic TNFAIP3 expression and exhibits complex chromatin architecture with over 30 predicted enhancers. This study aimed to functionally characterize an enhancer ∼55 kb… read more here.
Keywords: expression; tnfaip3; risk; enhancer upstream ... See more keywords
TNFAIP3 Reduction-of-Function Drives Female Infertility and CNS Inflammation
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DOI: 10.3389/fimmu.2022.811525
Abstract: Women with autoimmune and inflammatory aetiologies can exhibit reduced fecundity. TNFAIP3 is a master negative regulator of inflammation, and has been linked to many inflammatory conditions by genome wide associations studies, however its role in… read more here.
Keywords: inflammation; tnfaip3; fertility; tnfaip3 reduction ... See more keywords
TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.3869
Abstract: Tumor necrosis factor α induced protein 3 (TNFAIP3) is a protein that is induced by TNF-mediated NF-κB activation and has a dual function in regulating NF-κB. TNFAIP3 is associated with inflammatory carcinogenesis in many cancer types.… read more here.
Keywords: tnfaip3; poor survival; factor; cell ... See more keywords