Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2ab0420-572rr
Abstract: TNFR1 is a crucial regulator of NF‐ĸB‐mediated proinflammatory cell survival responses and programmed cell death (PCD). Deregulation of TNFα‐ and TNFR1‐controlled NF‐ĸB signaling underlies major diseases, like cancer, inflammation, and autoimmune diseases. Therefore, although being… read more here.
Keywords: single molecule; quantitative single; tnf; tnf induced ... See more keywords
Pre-clinical study of a TNFR1-targeted 18F probe for PET imaging of breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Amino Acids"
DOI: 10.1007/s00726-017-2526-y
Abstract: Tumor necrosis factor receptor 1 (TNFR1) is overexpressed in several varieties of carcinoma, including breast cancer. WH701 (Ala-Thr-Ala-Gln-Ser-Ala-Tyr-Gly), which was identified by phage display, can specifically bind to TNFR1. In this study, we labeled WH701… read more here.
Keywords: tnfr1; nota wh701; breast cancer; wh701 ... See more keywords
Inhibition of TNFR1 Attenuates LPS Induced Apoptosis and Inflammation in Human Nucleus Pulposus Cells by Regulating the NF-KB and MAPK Signalling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03278-1
Abstract: Intervertebral disc degeneration (IDD) is accompanied by nucleus pulposus (NP) cell apoptosis, inflammation, and extracellular matrix degradation. Tumour necrosis factor receptor 1 (TNFR1) is a receptor of TNF-α, and is deeply involved in the processes… read more here.
Keywords: tnfr1; mapk signalling; apoptosis inflammation;
TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100950
Abstract: Highlights • Elevated soluble TNFR1 levels are predictive of liver toxicity among patients receiving radiation.• Soluble TNFR1 levels do not independently predict liver toxicity when included in models with ALBI and mean liver dose.• Data… read more here.
Keywords: tnfr1; tnfr1 tnf; tnf axis; radiation ... See more keywords
Targeting Tumor Necrosis Factor Receptor 1 with Selected Aptamers for Anti-Inflammatory Activity.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00131
Abstract: Tumor necrosis factor-α (TNFα) inhibitors are widely used in treating autoimmune diseases like rheumatoid arthritis (RA). These inhibitors can presumably alleviate RA symptoms by blocking TNFα-TNF receptor 1 (TNFR1)-mediated pro-inflammatory signaling pathways. However, the strategy… read more here.
Keywords: tumor necrosis; anti inflammatory; tnfr1; necrosis factor ... See more keywords
TNFR1 inhibition with a Nanobody protects against EAE development in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13984-y
Abstract: TNF has as detrimental role in multiple sclerosis (MS), however, anti-TNF medication is not working. Selective TNF/TNFR1 inhibition whilst sparing TNFR2 signaling reduces the pro-inflammatory effects of TNF but preserves the important neuroprotective signals via… read more here.
Keywords: tnfr1; tnfr1 inhibition; nanobody; mice ... See more keywords
Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1111/imm.13400
Abstract: The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine‐rich domains (CRD) in their extracellular regions, and the membrane‐distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a pre‐ligand… read more here.
Keywords: tnfr1; plad; tnfr1 activity; homologous interactions ... See more keywords
Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210305
Abstract: Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the… read more here.
Keywords: tnfr1; inflammation; tumour necrosis; injury ... See more keywords
Abstract 429: Tnf Receptor-1 Dictates Life/death Decisions of Auto-reactive T-lymphocytes During Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.429
Abstract: Ischemic heart failure (HF) results in the activation of self-reactive CD4+ T-lymphocytes against unknown cardiac antigens. The mechanisms that mediate the survival of self-reactive T-cells during ischemic HF are not known. TNF mediated NF-kB signaling… read more here.
Keywords: tnfr1; tnf receptor; tnfr1 cells; heart failure ... See more keywords
Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1965-5
Abstract: BackgroundTumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to… read more here.
Keywords: tnfr1; tnfr1 tnf; tnfr1 complex; tnf tnfr1 ... See more keywords
TNFR1 single nucleotide polymorphisms are not associated with cervical HPV-induced pre-malignant lesion but regulate in situ cervical TNFR1 expression
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26627
Abstract: TNF-α is involved in HPV infection control by triggering cell signaling through binding in specific receptors TNFR1 and TNFR2. Genetic polymorphisms in these receptors may influence TNF-α signaling. Herein, we investigated TNFR1 rs767455 and rs2234649… read more here.
Keywords: tnfr1; nucleotide polymorphisms; single nucleotide; expression ... See more keywords