Mutations in the binding site of TNFR1 PLAD reduce homologous interactions but can enhance antagonism of wild‐type TNFR1 activity
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DOI: 10.1111/imm.13400
Abstract: The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine‐rich domains (CRD) in their extracellular regions, and the membrane‐distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a pre‐ligand… read more here.
Keywords: tnfr1; plad; tnfr1 activity; homologous interactions ... See more keywords