Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches
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DOI: 10.1186/s12967-019-1965-5
Abstract: BackgroundTumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to… read more here.
Keywords: tnfr1; tnfr1 tnf; tnfr1 complex; tnf tnfr1 ... See more keywords