TNFR1 inhibition with a Nanobody protects against EAE development in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13984-y
Abstract: TNF has as detrimental role in multiple sclerosis (MS), however, anti-TNF medication is not working. Selective TNF/TNFR1 inhibition whilst sparing TNFR2 signaling reduces the pro-inflammatory effects of TNF but preserves the important neuroprotective signals via… read more here.
Keywords: tnfr1; tnfr1 inhibition; nanobody; mice ... See more keywords
Tumour necrosis factor receptor 1 inhibition and cardiovascular disease: a cis-Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Preventive Cardiology"
DOI: 10.1093/eurjpc/zwad125.013
Abstract: Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Institute for Health and Care research (NIHR). Tumour necrosis factor receptor 1 (TNFR1) is a newly proposed drug target that has… read more here.
Keywords: inhibition; disease; mendelian randomization; crp ... See more keywords