TNFR1 and the TNFα axis as a targetable mediator of liver injury from stereotactic body radiation therapy
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2020.100950
Abstract: Highlights • Elevated soluble TNFR1 levels are predictive of liver toxicity among patients receiving radiation.• Soluble TNFR1 levels do not independently predict liver toxicity when included in models with ALBI and mean liver dose.• Data… read more here.
Keywords: tnfr1; tnfr1 tnf; tnf axis; radiation ... See more keywords
Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches
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DOI: 10.1186/s12967-019-1965-5
Abstract: BackgroundTumor necrosis factor α (TNFα) is a multifunctional cytokine with a potent pro-inflammatory effect. It is a validated therapeutic target molecule for several disorders related to autoimmunity and inflammation. TNFα–TNF receptor-1 (TNFR1) signaling contributes to… read more here.
Keywords: tnfr1; tnfr1 tnf; tnfr1 complex; tnf tnfr1 ... See more keywords
TNF Signaling Impacts Glucagon-Like Peptide-1 Expression and Secretion.
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DOI: 10.1530/jme-18-0129
Abstract: Numerous studies have implicated tumor necrosis factor α (TNFα) in the pathogenesis of type 2 diabetes. However, the role of its primary receptor, TNF receptor 1 (TNFR1), in homeostatic regulation of glucose metabolism is still… read more here.
Keywords: secretion; tnf; tnfr1 tnf; tnf signaling ... See more keywords