Dual neutralization of TNFR-2 and MMP-2 regulates the severity of S. aureus induced septic arthritis correlating alteration in the level of interferon gamma and interleukin-10 in terms of TNFR2 blocking
Sign Up to like & getrecommendations! Published in 2018 at "Immunologic Research"
DOI: 10.1007/s12026-017-8979-y
Abstract: Severity of S. aureus septic arthritis is correlated to prolonged inflammation by inflammatory cytokines like TNF-α, IL-1β, and IL-6 even after successful elimination of bacteria. Role of TNF-α via TNFR2 is not well established in… read more here.
Keywords: tnfr2; mmp; inflammatory cytokines; neutralization ... See more keywords
TNFR2-expressing CD4+Foxp3+ regulatory T cells in cancer immunology and immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.03.010
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) represent a major cellular mechanism in tumor immune evasion. Elimination of Treg activity has become a strategy to devise an effective tumor immunotherapy. We reported that TNF receptor type II… read more here.
Keywords: cd4 foxp3; foxp3 regulatory; tnfr2; immunology ... See more keywords
Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2016.11.083
Abstract: In multiple sclerosis (MS), soluble tumor necrosis factor (TNF) is detrimental via activation of TNF receptor 1 (TNFR1), whereas transmembrane TNF is beneficial primarily by activating TNF receptor 2 (TNFR2). Here, we investigate the role… read more here.
Keywords: macrophagic tnfr2; tnfr2; autoimmune encephalomyelitis; activation ... See more keywords
A TNFR2 antibody by countering immunosuppression cooperates with HMGN1 and R848 immune stimulants to inhibit murine colon cancer.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108345
Abstract: Immunosuppressive CD4+Foxp3+ regulatory T cells (Tregs) promote tumor immune evasion and thus targeting of Tregs has become an strategy in cancer immunotherapy. Tumor necrosis factor receptor 2 (TNFR2) is highly expressed and important for the… read more here.
Keywords: antibody countering; tnfr2; countering immunosuppression; cancer ... See more keywords
Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Orthopaedic Translation"
DOI: 10.1016/j.jot.2021.05.001
Abstract: Background Synovial inflammation plays a major role in the pathogenesis of osteoarthritis (OA). This study investigated the effect of andrographolide (Andro) on synovial inflammation mediated by tumor necrosis factor-alpha receptor 2 (TNFR2) trafficking and its… read more here.
Keywords: tnfr2; synovial inflammation; inflammation; tumor necrosis ... See more keywords
Regulatory T cells express Tumor Necrosis Factor Receptor 2 with the highest intensity among CD4+ T cells in the draining lymph nodes of breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.06.013
Abstract: Tumor Necrosis Factor Receptor 2 (TNFR2) is one of the receptors of TNF-α, which is expressed on various cell types. TNFR2 signaling has a balancing role between regulatory and effector functions of T cells. Herein,… read more here.
Keywords: cd4 cells; tnfr2; foxp3 cd25; cd4 ... See more keywords
Recombinant expression, purification and characterization of human soluble tumor necrosis factor receptor 2.
Sign Up to like & getrecommendations! Published in 2021 at "Protein expression and purification"
DOI: 10.1016/j.pep.2021.105857
Abstract: TNFR2 is aberrantly expressed on various cancer cells and highly immunosuppressive regulatory T cells (Tregs) accumulated in tumor microenvironment. As an oncoprotein and a stimulator of the immune checkpoint Tregs that promote cancer cell survival… read more here.
Keywords: tnfr2; human soluble; hstnfr2; expression purification ... See more keywords
Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0131-z
Abstract: Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF responsiveness in MF cells are unknown. We show that the proportion of marrow… read more here.
Keywords: tnf; tnfr2; tnf signaling; myelofibrosis ... See more keywords
TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Rheumatology"
DOI: 10.1093/rheumatology/keac124
Abstract: OBJECTIVES TNF-induced activation of fibroblast-like synoviocytes (FLS) is a critical determinant for synovial inflammation and joint destruction in rheumatoid arthritis (RA). The detrimental role of TNF-receptor 1 (TNFR1) has thoroughly been characterized. The contributions of… read more here.
Keywords: inflammation; tnf induced; tnf; expression ... See more keywords
Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aaf8608
Abstract: An antibody against TNFR2 may treat ovarian cancer by killing tumor cells while limiting the activity of suppressive immune cells. Killing ovarian cancer by trapping TNFR2 Signaling by tumor necrosis factor (TNF) family promotes tumor… read more here.
Keywords: tnfr2; proliferation; ovarian cancer; cancer cells ... See more keywords
Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aal2328
Abstract: Targeting TNF receptor type 2 may be a new avenue for treating ovarian cancer (Torrey et al., in 17 January 2017 issue). Tumor necrosis factor receptor 2 (TNFR2) is expressed both by some cancer cells… read more here.
Keywords: immune checkpoint; targeting tnfr2; tnfr2; tnfr2 immune ... See more keywords