Discovery of a Non-competitive TNFR1 Antagonist Affibody with Picomolar Monovalent Potency That Does Not Affect TNFR2 Function.
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DOI: 10.1021/acs.molpharmaceut.2c00385
Abstract: Tumor necrosis factor (TNF) is a key regulator of immune responses and plays a significant role in the initiation and maintenance of inflammation. Upregulation of TNF expression leads to several inflammatory diseases, such as Crohn's,… read more here.
Keywords: affibody; tnfr2 function; tnf; monovalent potency ... See more keywords