Discovery of 3,4-Dihydrobenzo[f][1,4]oxazepin-5(2H)-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00672
Abstract: The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer (CRC) that is often… read more here.
Keywords: dihydrobenzo oxazepin; oxazepin one; tnik inhibitors; colorectal cancer ... See more keywords
De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c07937
Abstract: Bioengineering of ribosomally synthesized and post-translationally modified peptides (RiPPs) is an emerging approach to explore the diversity of pseudo-natural product structures for drug discovery purposes. However, despite the initial advances in this area, bioactivity reprogramming… read more here.
Keywords: novo discovery; natural products; pseudo natural; kinase ... See more keywords
Abstract 1123: TRAF2 and NCK-interacting protein kinase (TNIK) regulates cancer stemness and adipogenesis of osteosarcoma cells
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DOI: 10.1158/1538-7445.am2018-1123
Abstract: [Introduction] Osteosarcoma (OS) is a rare malignant bone tumor and affects predominantly adolescents and young adults. There is no molecular targeted therapy for OS and breakthrough intervention has long been awaited for decades. Disturbances in… read more here.
Keywords: tnik; tnik inhibitor; osteosarcoma; cancer ... See more keywords
Abstract 1125: TNIK induced chemoradiation resistance in small cell lung cancer
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DOI: 10.1158/1538-7445.am2024-1125
Abstract: Chemoradiation (CRT) is the standard first-line therapy for limited stage small cell lung cancer (LS-SCLC), which is characterized by early metastasis, intrinsic-acquired CRT resistance and tumor recurrence. CRT confers a 20-25% 5-year overall survival in… read more here.
Keywords: cancer; resistance; tnik; small cell ... See more keywords
Abstract 2818: Investigating the role of TNIK in the pathogenesis of lung squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-2818
Abstract: Lung squamous cell carcinoma (LSCC) is the second most prevalent type of lung cancer with no FDA-approved targeted therapies. Platinum-based chemotherapy and immunotherapy remain the cornerstone of current treatments for advanced LSCC, and the 5-year… read more here.
Keywords: lung; tnik; squamous cell; cell carcinoma ... See more keywords
Abstract 04: Renal- and TAL-Specific Inhibition of Traf2 and NCK Interacting Kinase (TNIK) Decreases NKKC2 Phosphorylation and Blunts Salt-Sensitive Hypertension in Dahl Salt-Sensitive Rats
Sign Up to like & getrecommendations! Published in 2024 at "Hypertension"
DOI: 10.1161/hyp.81.suppl_1.04
Abstract: Up to 50% of hypertensive patients are salt-sensitive. Abnormally enhanced NaCl reabsorption by the thick ascending limb of the loop of Henle (TAL) in the kidney contributes to the development of salt-sensitivity. NaCl reabsorption in… read more here.
Keywords: tnik; phosphorylation; salt sensitive; expression ... See more keywords
Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1359154
Abstract: A large number of synaptic proteins have been recurrently associated with complex brain disorders. One of these proteins, the Traf and Nck interacting kinase (TNIK), is a postsynaptic density (PSD) signaling hub, with many variants… read more here.
Keywords: signaling hub; psd signaling; tnik; postsynaptic density ... See more keywords
Feasibility of Targeting Traf2-and-Nck-Interacting Kinase in Synovial Sarcoma
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DOI: 10.3390/cancers12051258
Abstract: Background: The treatment of patients with metastatic synovial sarcoma is still challenging, and the development of new molecular therapeutics is desirable. Dysregulation of Wnt signaling has been implicated in synovial sarcoma. Traf2-and-Nck-interacting kinase (TNIK) is… read more here.
Keywords: sarcoma; tnik; nck interacting; synovial sarcoma ... See more keywords
Structural Insight into TNIK Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113010
Abstract: TRAF2- and NCK-interacting kinase (TNIK) has emerged as a promising therapeutic target for colorectal cancer because of its essential role in regulating the Wnt/β-catenin signaling pathway. Colorectal cancers contain many mutations in the Wnt/β-catenin signaling… read more here.
Keywords: inhibition; structural insight; wnt catenin; tnik ... See more keywords