Switching from alteplase to tenecteplase for stroke thrombolysis: short-term effects on treatment metrics and early functional outcomes
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DOI: 10.1186/s12883-025-04529-2
Abstract: Besides its more advantageous pharmacological profile compared to alteplase (rt-PA), increasing evidence suggest a favorable clinical efficacy and safety of tenecteplase (TNK) as alternative thrombolytic agent for the treatment of acute ischemic stroke (AIS). We… read more here.
Keywords: treatment; tnk; early functional; functional outcomes ... See more keywords
Safety and Efficacy of Tenecteplase in Older Patients With Large Vessel Occlusion
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DOI: 10.1212/wnl.0000000000013302
Abstract: Background and Objectives Detailed study of tenecteplase (TNK) in patients older than 80 years is limited. The objective of our study was to assess the safety and efficacy of TNK at 0.25 and 0.40 mg/kg… read more here.
Keywords: large vessel; day; tnk; occlusion ... See more keywords
Safety and Efficacy of Tenecteplase and Alteplase in Patients With Tandem Lesion Stroke
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DOI: 10.1212/wnl.0000000000207138
Abstract: Background and Objectives The safety and efficacy of tenecteplase (TNK) in patients with tandem lesion (TL) stroke is unknown. We performed a comparative analysis of TNK and alteplase in patients with TLs. Methods We first… read more here.
Keywords: alteplase; tnk; efficacy tenecteplase; safety efficacy ... See more keywords
Tenecteplase vs Alteplase in Acute Ischemic Stroke Within 4.5 Hours
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DOI: 10.1212/wnl.0000000000209903
Abstract: Background and Objectives The current European Stroke Organisation expedited recommendation on tenecteplase (TNK) for acute ischemic stroke (AIS) advocates that TNK 0.25 mg/kg can be used alternatively to alteplase (tissue plasminogen activator [TPA]) for AIS… read more here.
Keywords: functional outcome; acute ischemic; tnk; ischemic stroke ... See more keywords
Short-Term Efficacy Outcomes of Tenecteplase versus Alteplase for Acute Ischemic Stroke: A Meta-Analysis of 5 Randomized Trials.
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DOI: 10.4103/0028-3886.355108
Abstract: Tenecteplase (TNK) has been shown to be noninferior to Alteplase (ALT) for long term efficacy and safety outcomes. Whether this also applies to short term efficacy outcomes such as early clinical improvement and recanalization is… read more here.
Keywords: tnk; efficacy outcomes; term; term efficacy ... See more keywords