Abstract 3489: TNK1 is a ubiquitin sensing kinase that can be targeted in vivo to block tumor growth
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DOI: 10.1158/1538-7445.am2023-3489
Abstract: Thirty eight negative kinase 1 (TNK1) is an understudied non-receptor tyrosine kinase with no established function or mechanism of regulation. Our recent publication reported TNK1 as the primary kinase driver of cell survival in subsets… read more here.
Keywords: growth; tnk1; kinase; domain ... See more keywords
Abstract 5029: Determining the biological function of TNK1
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DOI: 10.1158/1538-7445.am2023-5029
Abstract: Thirty-eight-negative kinase 1 (TNK1) is a poorly characterized member of the ACK family of non-receptor tyrosine kinases, which we recently identified as a driver of cell survival in a subset of primary hematological malignancies. However,… read more here.
Keywords: function; tnk1; uba domain; biological function ... See more keywords
Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock
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DOI: 10.3389/fimmu.2020.02081
Abstract: Trauma represents a major socioeconomic burden worldwide. After a severe injury, hemorrhagic shock (HS) as a frequent concomitant aspect is a central driver of systemic inflammation and organ damage. The kidney is often strongly affected… read more here.
Keywords: kidney injury; non human; tnk1; trauma ... See more keywords