Knockout of cardiac troponin I‐interacting kinase leads to cardiac dysfunction and remodelling
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13699
Abstract: Cardiac troponin I‐interacting kinase (TNNI3K) is a cardiac‐specific kinase that has been identified as a diagnostic marker and a therapeutic target in cardiovascular diseases. However, the biological function of TNNI3K in cardiac dysfunction and remodelling… read more here.
Keywords: tnni3k; kinase; troponin interacting; cardiac dysfunction ... See more keywords
Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000456400
Abstract: Backgroud/Aims: The biological function of cardiac troponin I-interacting kinase (TNNI3K), a cardiac-specific functional kinase, is largely unknown. We investigated the effect of human TNNI3K (hTNNI3K) on the differentiation of mouse embryonic stem cells (mESCs) into… read more here.
Keywords: kinase tnni3k; tnni3k; cardiac specific; overexpression ... See more keywords
Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency
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DOI: 10.1371/journal.pgen.1008354
Abstract: Recent evidence implicates mononuclear diploid cardiomyocytes as a proliferative and regenerative subpopulation of the postnatal heart. The number of these cardiomyocytes is a complex trait showing substantial natural variation among inbred mouse strains based on… read more here.
Keywords: kinase; tnni3k; diploid cardiomyocyte; mononuclear diploid ... See more keywords
Whole-Exome Sequencing Identifies a Novel Variant (c.1538T > C) of TNNI3K in Arrhythmogenic Right Ventricular Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.843837
Abstract: Backgrounds Arrhythmic right ventricular cardiomyopathy (ARVC) is a cardiomyopathy with a genetic predisposition that can lead to a sudden cardiac death and heart failure. According to the 2010 Task Force Criteria, genetic diagnosis is one… read more here.
Keywords: tnni3k; ventricular cardiomyopathy; whole exome; right ventricular ... See more keywords