Toad venom bufadienolides and bufotoxins: An updated review.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22072
Abstract: Bufadienolides, naturally found in toad venoms having steroid-like structures, reveal antiproliferative effects at low doses. However, their application as anticancer drugs is strongly prevented by their Na+ /K+ -ATPase binding activities. Although several kinds of… read more here.
Keywords: venom bufadienolides; review; toad venom; bufadienolides bufotoxins ... See more keywords
A strategy for the metabolomics-based screening of active constituents and quality consistency control for natural medicinal substance toad venom.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.05.054
Abstract: Natural medicinal substances (NMS) have great inconsistency due to chemical variability, seriously limiting their development as therapeutics. Here, we chose toad venom with anti-tumor activities as a model and developed a pipeline of metabolomics-based screening… read more here.
Keywords: toad venom; venom; control; natural medicinal ... See more keywords
Anti-tumor effects and 3D-quantitative structure-activity relationship analysis of bufadienolides from toad venom.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.03.006
Abstract: Toad venom (venenum bufonis, also called Chan'su) has been widely used for centuries in China to treat different diseases, especially for cancer. Bufadienolides are mainly responsible for the anti-cancer effects of toad venom. However, systematic… read more here.
Keywords: toad venom; relationship; anti tumor; structure ... See more keywords
Evaluation of analgesic and anti-inflammatory actions of indolealkylamines from toad venom in mice using lipidomics and molecular docking.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.113677
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Toad venom is one of widely used traditional Chinese medicines due to its analgesic and anti-inflammatory activities. However, hydrophilic alkaloids from toad venom, which may have certain pharmacological activities, have not been systematic… read more here.
Keywords: anti inflammatory; inflammatory actions; toad venom; analgesic anti ... See more keywords
Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2023.1137547
Abstract: Cancer is the second leading cause of death worldwide. Specially, the high incidence rate and prevalence of drug resistance have rendered prostate cancer (PCa) a great threat to men’s health. Novel modalities with different structures… read more here.
Keywords: application; venom derived; toad venom; pca ... See more keywords
Identification of Protein Quality Markers in Toad Venom from Bufo gargarizans
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28083628
Abstract: Toad venom is a traditional Chinese medicine with high medicinal value. The existing quality evaluation standards of toad venom have obvious limitations because of the lack of research on proteins. Thus, it is necessary to… read more here.
Keywords: quality; toad venom; venom proteins; quality evaluation ... See more keywords