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   Articles with "tobacco specific" as a keyword



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Magnetic solid phase extraction of tobacco-specific N-nitrosamines using magnetic graphene composite as sorbent.

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recommendations! Published in 2019 at "Journal of separation science"

DOI: 10.1002/jssc.201900438

Abstract: Tobacco-specific N-nitrosamines are carcinogenic components in mainstream cigarette smoke. To explore tobacco-specific N-nitrosamine release levels in cigarettes, a magnetic solid-phase extraction procedure using magnetic graphene composite as sorbent for fast enrichment of tobacco-specific N-nitrosamine was… read more here.

Keywords: tobacco; phase extraction; magnetic solid; solid phase ... See more keywords
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Facilitated tobacco-specific nitrosamine formation from nicotine in the presence of Cu2+ ions

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recommendations! Published in 2018 at "Industrial Crops and Products"

DOI: 10.1016/j.indcrop.2018.06.022

Abstract: Abstract Regular practice in tobacco farming recognizes that copper is one of the essential micronutrients in tobacco ( Nicotiana tabacum ). We report here that copper is present in significant levels in post-harvested, cured tobacco.… read more here.

Keywords: tobacco; specific nitrosamine; formation; tobacco specific ... See more keywords
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New efficient selective adsorbent of tobacco specific nitrosamines derived from discarded cigarette filters

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recommendations! Published in 2019 at "Microporous and Mesoporous Materials"

DOI: 10.1016/j.micromeso.2019.04.060

Abstract: Abstract To expand the application of the principle of selective adsorption, new hierarchical porous carbon was fabricated from cigarette filters and cheap metal salts via one-pot synthesis, in order to selectively capture the tobacco-specific nitrosamines… read more here.

Keywords: tobacco; tobacco specific; cigarette filters; carbon ... See more keywords
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Liquid Chromatography-Tandem Mass Spectrometry for the Quantification of Tobacco-Specific Nitrosamine-Induced DNA Adducts in Mammalian Cells.

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recommendations! Published in 2017 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.7b01857

Abstract: Quantification of DNA lesions constitutes one of the main tasks in toxicology and in assessing health risks accompanied by exposure to carcinogens. Tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN) can undergo metabolic transformation to give… read more here.

Keywords: pobdt; dna; tobacco specific; liquid chromatography ... See more keywords
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In Vivo Stable-Isotope Labeling and Mass-Spectrometry-Based Metabolic Profiling of a Potent Tobacco-Specific Carcinogen in Rats.

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recommendations! Published in 2018 at "Analytical chemistry"

DOI: 10.1021/acs.analchem.8b01881

Abstract: The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a potent lung carcinogen that exerts its carcinogenic effects upon metabolic activation. The identification and quantitation of NNK metabolites could identify potential biomarkers of bioactivation and detoxification of this… read more here.

Keywords: isotope labeling; mass spectrometry; nnk metabolites; tobacco specific ... See more keywords
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Influence of Nitrite on Formation of Tobacco-Specific Nitrosamines in Electronic Cigarette Liquids and Aerosols

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recommendations! Published in 2022 at "Chemical Research in Toxicology"

DOI: 10.1021/acs.chemrestox.1c00417

Abstract: Tobacco-specific nitrosamine (TSNA) formation occurred during aerosol generation from select commercial cig-a-like e-cigarette products. To understand the drivers behind the potential formation of TSNAs in electronic cigarette (e-cigarette) aerosols and e-liquids, model e-liquid systems were… read more here.

Keywords: electronic cigarette; cigarette; formation; tobacco specific ... See more keywords
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Thirdhand Exposures to Tobacco-Specific Nitrosamines through Inhalation, Dust Ingestion, Dermal Uptake, and Epidermal Chemistry.

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recommendations! Published in 2022 at "Environmental science & technology"

DOI: 10.1021/acs.est.2c02559

Abstract: Tobacco-specific nitrosamines (TSNAs) are emitted during smoking and form indoors by nitrosation of nicotine. Two of them, N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are human carcinogens with No Significant Risk Levels (NSRLs) of 500 and 14… read more here.

Keywords: dust; dermal uptake; epidermal chemistry; chemistry ... See more keywords
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Creating an Optimal Microenvironment within Mesoporous Silica MCM-41 for Capture of Tobacco-Specific Nitrosamines in Solution.

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recommendations! Published in 2017 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.7b06264

Abstract: To meet the requirement of capturing tobacco-specific nitrosamines (TSNA) for environment protection, a unique microenvironment was carefully created inside the channels of mesoporous silica MCM-41. In situ carbonization of template micelles at 923 K, combined… read more here.

Keywords: tobacco; microenvironment; tobacco specific; mcm ... See more keywords
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Urinary tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and cognitive functioning in older adults: The National Health and Nutrition Examination Survey 2013–2014

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recommendations! Published in 2023 at "Tobacco Induced Diseases"

DOI: 10.18332/tid/162368

Abstract: INTRODUCTION Tobacco contains carcinogens called tobacco-specific nitrosamines. Among the tobacco-specific nitrosamines, is nicotine-derived nitrosamine ketone (NNK) which produces the metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). We aimed to examine the association between urinary tobacco-specific NNAL and cognitive functioning… read more here.

Keywords: nnal cognitive; urinary tobacco; older adults; tobacco ... See more keywords
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CLCNt2 Mediates Nitrate Content in Tobacco Leaf, Impacting the Production of Tobacco-Specific Nitrosamines in Cured Leaves

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recommendations! Published in 2022 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2022.741078

Abstract: Nitrate accumulation in tobacco (Nicotiana tabacum L.) leaf, particularly in the burley (BU) type, is a reservoir for the generation of nitrosating agents responsible for the formation of tobacco-specific nitrosamines (TSNAs). TSNAs are mainly produced… read more here.

Keywords: specific nitrosamines; cured leaves; tobacco leaf; tobacco ... See more keywords
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Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23095109

Abstract: The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco products or in environments contaminated by tobacco smoke. They have been classified as “carcinogenic to humans” by the International Agency… read more here.

Keywords: tobacco specific; metabolism dna; specific nitrosamines; tobacco ... See more keywords