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   Articles with "tobramycin" as a keyword



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Determination of tobramycin in eye drops with an open-source hardware ion mobility spectrometer

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recommendations! Published in 2022 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-022-04050-2

Abstract: The analysis of tobramycin was demonstrated successfully as an example for electrospray ionization on an open-source hardware ion mobility spectrometer. This instrument was assembled inexpensively in-house, and required only very few purpose-made components. The quantitative… read more here.

Keywords: mobility spectrometer; tobramycin; source hardware; ion mobility ... See more keywords
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An Enhanced Direct Competitive Immunoassay for the Detection of Kanamycin and Tobramycin in Milk Using Multienzyme-Particle Amplification

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recommendations! Published in 2018 at "Food Analytical Methods"

DOI: 10.1007/s12161-018-1185-2

Abstract: Kanamycin (Kan) and tobramycin (Tob) are widely found in many foods of animal origin, including milk. More rapid, simple, and sensitive methods are urgently needed to monitor antibiotic residues in milk. An enhanced direct competitive… read more here.

Keywords: milk; hrp kan; tobramycin; enhanced direct ... See more keywords
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Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption.

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recommendations! Published in 2018 at "International journal of antimicrobial agents"

DOI: 10.1016/j.ijantimicag.2017.11.004

Abstract: Oral antibiotics for the treatment of urinary tract infections are scarce. In this ex vivo phase 1 annex study, the clinical safety, urinary concentrations and bactericidal activity of a new formulation for improved oral absorption… read more here.

Keywords: urinary concentrations; absorption; tobramycin; formulation improved ... See more keywords

Incorporating Fullerenes in Nanoscale Metal-Organic Matrixes: An Ultrasensitive Platform for Impedimetric Aptasensing of Tobramycin.

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recommendations! Published in 2022 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.1c23320

Abstract: The rational design and preparation of available fullerene@metal-organic matrix hybrid materials are of profound significance in electrochemical biosensing applications due to their unique photoelectric properties. In this work, C60@UiO-66-NH2 nanocomposites serve as greatly promising materials… read more here.

Keywords: fullerenes nanoscale; tobramycin; incorporating fullerenes; metal organic ... See more keywords

Liquid Crystal Nanoparticles Enhance Tobramycin Efficacy in a Murine Model of Pseudomonas aeruginosa Biofilm Wound Infection.

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recommendations! Published in 2022 at "ACS infectious diseases"

DOI: 10.1021/acsinfecdis.1c00606

Abstract: Chronic Pseudomonas aeruginosa wound infections are highly prevalent and often untreatable due to biofilm formation, resulting in high antimicrobial tolerance. Standard antibiotic therapy for P. aeruginosa infections involves tobramycin, yet it is highly ineffective as… read more here.

Keywords: tobramycin; aeruginosa biofilm; lcnps; infection ... See more keywords
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Bayesian forecasting for intravenous tobramycin dosing in adults with cystic fibrosis using one versus two serum concentrations in a dosing interval.

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recommendations! Published in 2021 at "Therapeutic drug monitoring"

DOI: 10.1097/ftd.0000000000000900

Abstract: BACKGROUND Intravenous tobramycin treatment requires therapeutic drug monitoring (TDM) to ensure safety and efficacy when used for prolonged treatment, as in infective exacerbations of cystic fibrosis (CF). The 24-h area under the concentration-time curve (AUC24)… read more here.

Keywords: cystic fibrosis; auc24; tobramycin; intravenous tobramycin ... See more keywords
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Tobramycin and antiglaucoma agents as increasing culprits of periorbital allergic contact dermatitis from topical ophthalmic medications: A 24-year study from Turkey.

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recommendations! Published in 2023 at "Contact dermatitis"

DOI: 10.1111/cod.14309

Abstract: BACKGROUND Allergic contact dermatitis (ACD) from topical ophthalmic medications (TOMs) poses an additional disease burden to patients who already suffer from eye problems. OBJECTIVES To investigate the epidemiological/clinical profile of patients with periorbital ACD from… read more here.

Keywords: tobramycin; ophthalmic medications; contact dermatitis; allergic contact ... See more keywords
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Use of Calgary and Microfluidic BioFlux Systems To Test the Activity of Fosfomycin and Tobramycin Alone and in Combination against Cystic Fibrosis Pseudomonas aeruginosa Biofilms

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recommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01650-17

Abstract: ABSTRACT Pseudomonas aeruginosa is a major cause of morbidity and mortality in chronically infected cystic fibrosis patients. Novel in vitro biofilm models which reliably predict the therapeutic success of antimicrobial therapies against biofilm bacteria should… read more here.

Keywords: combination; cystic fibrosis; tobramycin; fosfomycin ... See more keywords
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A Pharmacokinetic Analysis of Tobramycin in Patients Less than Five Years of Age with Cystic Fibrosis: Assessment of Target Attainment with Extended-Interval Dosing through Simulation

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recommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.02377-21

Abstract: Extended interval dosing of tobramycin is recommended for treatment of pulmonary exacerbations in adults and older children with cystic fibrosis (CF), but data are limited in patients less than 5 years of age. We performed a… read more here.

Keywords: tobramycin; interval dosing; years age; age ... See more keywords
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Acute Infection with a Tobramycin-Induced Small Colony Variant of Staphylococcus aureus Causes Increased Inflammation in the Cystic Fibrosis Rat Lung

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recommendations! Published in 2022 at "Infection and Immunity"

DOI: 10.1128/iai.00237-22

Abstract: Cystic fibrosis (CF) disease is characterized by lifelong infections with pathogens such as Staphylococcus aureus, leading to eventual respiratory failure. Small colony variants (SCVs) of S. aureus have been linked to worse clinical outcomes for… read more here.

Keywords: tobramycin; staphylococcus aureus; small colony; colony ... See more keywords
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Evaluation of an alkali-treated and hydroxyapatite-coated orthopedic implant loaded with tobramycin

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recommendations! Published in 2019 at "Journal of Biomaterials Applications"

DOI: 10.1177/0885328219867968

Abstract: An approximately 1-µm thick hydroxyapatite coating was biomimetically deposited on an alkali-treated, commercially available orthopedic screw surface (type II anodized titanium). Tobramycin loaded into the coating via a simple soaking method was shown to provide… read more here.

Keywords: loaded coating; tobramycin loaded; tobramycin; evaluation alkali ... See more keywords