Does Circadian Rhythm affect the Pharmacokinetics of Once-Daily Tobramycin in Adults with Cystic Fibrosis?
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DOI: 10.1097/ftd.0000000000000743
Abstract: BACKGROUND In the era of multiple daily dosing of systemic aminoglycosides, a circadian rhythm in the clearance of these vital antibiotics has been demonstrated in animals and healthy volunteers. Over the past decade, once-daily dosing… read more here.
Keywords: adults cystic; daily tobramycin; cystic fibrosis; tobramycin adults ... See more keywords