Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-0619
Abstract: Purpose: Toca 511 is a gammaretroviral replicating vector encoding cytosine deaminase that selectively infects tumor cells and converts the antifungal drug 5-fluorocytosine into the antineoplastic drug 5-fluorouracil, which directly kills tumor cells and stimulates antitumor… read more here.
Keywords: molecular analyses; tumor; replicating vector; toca 511 ... See more keywords
Immune modulation after Toca 511 and Toca FC treatment of colorectal cancer patients.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.186
Abstract: 186Background: Toca 511 (vocimagene amiretrorepvec) is a cancer-selective, retroviral replicating vector encoding yeast cytosine deaminase that converts 5-fluorocytosine (5-FC) into 5-fluorouracil ... read more here.
Keywords: modulation toca; immune modulation; toca 511; 511 toca ... See more keywords