Efficacy of tocilizumab in the treatment of COVID‐19: An umbrella review
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DOI: 10.1002/rmv.2388
Abstract: Tocilizumab is an interleukin (IL)‐6 receptor inhibitor that has been proposed as a therapeutic agent for treating coronavirus disease 2019 (COVID‐19). The aim of this umbrella review was to determine the efficacy of tocilizumab in… read more here.
Keywords: review; efficacy tocilizumab; tocilizumab; umbrella review ... See more keywords
[Fatal course of COVID-19 despite IL-6 receptor blockade in cytokine storm : Perimyocarditis and coagulopathy after administration of tocilizumab].
Sign Up to like & getrecommendations! Published in 2020 at "Der Anaesthesist"
DOI: 10.1007/s00101-020-00871-x
Abstract: A 59-year-old male patient was admitted to hospital diagnosed with moderate pneumonia associated with COVID-19. Upfront treatment with hydroxychloroquine and azithromycin was started. Due to a clinical deterioration (ARDS, circulatory shock) and greatly increased inflammation markers… read more here.
Keywords: treatment; cytokine storm; covid; tocilizumab ... See more keywords
Tocilizumab in transplantation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02864-6
Abstract: Purpose Tocilizumab, a monoclonal antibody directed against the IL-6 receptor, might block detrimental effects of IL-6 on transplantation. IL-6 plays a considerable role in cytokine storm after stem cell transplantation as well as graft versus… read more here.
Keywords: pharmacology; transplantation; tocilizumab transplantation; tocilizumab ... See more keywords
Interleukin-6 in idiopathic multicentric Castleman’s disease after long-term tocilizumab
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DOI: 10.1007/s00277-017-3111-x
Abstract: Dear Editor, Idiopathic multicentric Castleman’s disease (iMCD) is a poorly understood lymphoproliferative disorder driven by the overrepresentation of interleukin (IL)-6 [1–5]. Since IL-6 plays a central role in the pathogenesis of iMCD, the normalization of… read more here.
Keywords: median level; range; long term; disease ... See more keywords
Differential effects of inhibition of interleukin 1 and 6 on myocardial, coronary and vascular function
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DOI: 10.1007/s00392-019-01443-9
Abstract: BackgroundAnakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis. We investigated the differential effects of anakinra and tocilizumab on myocardial and vascular function in an… read more here.
Keywords: longitudinal strain; differential effects; treatment; vascular function ... See more keywords
Real-world experience of tocilizumab in rheumatoid arthritis: sub-analysis of data from the Italian biologics’ register GISEA
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DOI: 10.1007/s10067-017-3846-8
Abstract: To assess the long-term effectiveness and safety of tocilizumab, abatacept, and tumor necrosis factor-α inhibitors (TNFi), in the Italian real-world setting of rheumatoid arthritis (RA). The records of adult RA patients from the Italian biologics’… read more here.
Keywords: real world; italian biologics; tocilizumab; rheumatoid arthritis ... See more keywords
Effect of Tocilizumab Treatment on Patients with Coronavirus Disease 2019 and Bacteremia: A Retrospective Cohort Study
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DOI: 10.1007/s40121-022-00592-1
Abstract: Introduction This study aimed to determine if tocilizumab treatment for coronavirus disease 2019 (COVID-19) increases bacteremia and suppresses fever and inflammatory reactants. Methods In this single-center, retrospective, observational study, all patients with COVID-19 admitted to… read more here.
Keywords: study; bacteremia; tocilizumab; tocilizumab treatment ... See more keywords
ACTIVE TB AFTER THE USE OF TOCILIZUMAB FOR COVID-19 INFECTION
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DOI: 10.1016/j.chest.2021.07.295
Abstract: TOPIC: Chest Infections TYPE: Fellow Case Reports INTRODUCTION: Tocilizumab is a humanized anti-IL-6 receptor antibody and inhibits the binding of IL-6 to its receptors, associated with Th17 and Th22 cell differentiation which is critical for… read more here.
Keywords: use tocilizumab; covid infection; tuberculosis; tocilizumab ... See more keywords
Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis
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DOI: 10.1016/j.cmi.2020.10.036
Abstract: Background Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated with multi-organ damage and death in severe COVID-19 disease. Objectives To perform a living systematic review of the literature about the efficacy and toxicity… read more here.
Keywords: covid patients; risk; review; tocilizumab ... See more keywords
Early use of low dose tocilizumab in patients with COVID-19: A retrospective cohort study with a complete follow-up
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DOI: 10.1016/j.eclinm.2020.100459
Abstract: Abstract Background Pneumonia with severe respiratory failure represents the principal cause of death in COVID-19, where hyper-inflammation plays an important role in lung damage. An effective treatment aiming at reducing the inflammation without preventing virus… read more here.
Keywords: retrospective cohort; treatment; tocilizumab; patients covid ... See more keywords
Tocilizumab in SARS-COVID19 following postoperative laparoscopic transhiatal esophagectomy for the adenocarcinoma of esophagogastric tumor: A case report
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DOI: 10.1016/j.ijscr.2021.106343
Abstract: Introduction and importance Esophagectomy for esophageal cancer is one of the most challenging surgical procedures, with high rates of morbidity, especially from respiratory complications. SARS-COVID19 represents a health threat nowadays. Peri-operative SARS-COVID19 infection after esophagectomy… read more here.
Keywords: adenocarcinoma esophagogastric; laparoscopic transhiatal; esophagectomy; sars covid19 ... See more keywords