Vitamin E analogues differentially inhibit human cytochrome P450 3A (CYP3A)-mediated oxidative metabolism of lithocholic acid: Impact of δ-tocotrienol on lithocholic acid cytotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology"
DOI: 10.1016/j.tox.2019.05.005
Abstract: Lithocholic acid is a cytotoxic bile acid oxidized at the C-3 position by human cytochrome P450 3A (CYP3A) to form 3-ketocholanoic acid, but it is not known whether this metabolite is cytotoxic. Tocotrienols, in their… read more here.
Keywords: tocotrienol; lithocholic acid; vitamin; acid ... See more keywords
An evaluation of tocotrienol ethosomes for transdermal delivery using Strat-M® membrane and excised human skin
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2020.1860087
Abstract: Abstract Tocotrienol (TRF) ethosomes were developed and evaluated in vitro for potential transdermal delivery against melanoma. The optimised TRF ethosomal size ranged between 64.9 ± 2.2 nm to 79.6 ± 3.9 nm and zeta potential (ZP) between −53.3 mV to −62.0 ± 2.6 mV. Characterisation… read more here.
Keywords: transdermal delivery; significantly higher; tocotrienol; human skin ... See more keywords
Vitamin E Improves Neurite Complexity by Enhancing Mitochondrial Function
Sign Up to like & getrecommendations! Published in 2021 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzab049_028
Abstract: Neurite outgrowth is a foundational process in brain development and recovery from brain injury. Assembly of the cytoskeleton and formation of new synapses during neurite outgrowth requires an abundance of energy. We have reported that… read more here.
Keywords: mitochondrial function; alpha tocotrienol; neurite complexity; tocotrienol ... See more keywords
Tocotrienol-Rich Fraction (TRF) Treatment Promotes Proliferation Capacity of Stress-Induced Premature Senescence Myoblasts and Modulates the Renewal of Satellite Cells: Microarray Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/9141343
Abstract: Human skeletal muscle is a vital organ involved in movement and force generation. It suffers from deterioration in mass, strength, and regenerative capacity in sarcopenia. Skeletal muscle satellite cells are involved in the regeneration process… read more here.
Keywords: capacity; trf treatment; treatment; tocotrienol ... See more keywords
Abstract 2889: γ-Tocotrienol inhibition of metastatic phenotypic behavior is associated with a decrease in galectin-3 expression and distribution in the highly malignant mouse +SA & TS/A mammary tumor cells
Sign Up to like & getrecommendations! Published in 2021 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2021-2889
Abstract: γ-Tocotrienol is a rare natural isoform of vitamin E that displays potent apoptotic and anti-metastatic activity against breast cancer. Galectin-3 is a protein that plays an important role in metastasis by binding to glycoconjugates on… read more here.
Keywords: treatment; tocotrienol; galectin; tumor ... See more keywords
The Effect of Palm Tocotrienol on Surface Osteoblast and Osteoclast in Excess Glucocorticoid Osteoporotic Rat Model
Sign Up to like & getrecommendations! Published in 2018 at "Sains Malaysiana"
DOI: 10.17576/jsm-2018-4711-16
Abstract: A balanced interaction between osteoblast and osteoclast plays a major role in maintaining bone strength and structural integrity. Tocotrienol, a palm derivative with potent antioxidant properties showed an anti-osteoporotic effect but little is known about… read more here.
Keywords: osteoblast osteoclast; palm tocotrienol; adrx dexa; tocotrienol ... See more keywords
Comparing the Effects of Alpha-Tocopherol and Tocotrienol Isomers on Osteoblasts hFOB 1.19 Cultured on Bovine Bone Scaffold
Sign Up to like & getrecommendations! Published in 2021 at "Sains Malaysiana"
DOI: 10.17576/jsm-2021-5008-15
Abstract: Tocotrienol mixtures have been shown to exert anabolic actions on the skeletal system in animal studies, but it is unclear which tocotrienol isomer shows the most prominent effects. This study aims to investigate the most… read more here.
Keywords: tocotrienol isomers; cultured bovine; tocotrienol; bone ... See more keywords
A Redox-Silent Analogue of Tocotrienol May Break the Homeostasis of Proteasomes in Human Malignant Mesothelioma Cells by Inhibiting STAT3 and NRF1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052655
Abstract: 6-O-Carboxypropyl-alpha-tocotrienol (α-T3E) is a multi-target redox-silent analogue of tocotrienol that exhibits cytotoxicity against many cancer cells, including malignant mesothelioma (MM) cells. α-T3E has several molecular targets to effectively induce cytotoxicity against MM cells; however, the… read more here.
Keywords: mesothelioma; homeostasis proteasomes; redox silent; homeostasis ... See more keywords
Transcriptomic Analysis of the Anticancer Effects of Annatto Tocotrienol, Delta-Tocotrienol and Gamma-Tocotrienol on Chondrosarcoma Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14204277
Abstract: Previous studies have demonstrated the anticancer activities of tocotrienol on several types of cancer, but its effects on chondrosarcoma have never been investigated. Therefore, this study aims to determine the anticancer properties of annatto tocotrienol… read more here.
Keywords: sw1353 cells; analysis; chondrosarcoma; anticancer ... See more keywords
Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15081854
Abstract: Background: Tocotrienol, a type of vitamin E, is well known for its anti-cancer and other biological activities. This systematic review aims to summarize the involvement of endoplasmic reticulum stress (ERS) and subsequent unfolded protein response… read more here.
Keywords: endoplasmic reticulum; mechanism tocotrienol; tocotrienol; molecular mechanism ... See more keywords
The Role of Tocotrienol in Arthritis Management—A Scoping Review of Literature
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030385
Abstract: Arthritis is a cluster of diseases impacting joint health and causing immobility and morbidity in the elderly. Among the various forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common. Currently, satisfying… read more here.
Keywords: effects tocotrienol; tocotrienol arthritis; scoping review; literature ... See more keywords