A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
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DOI: 10.1007/s11095-019-2587-6
Abstract: BackgroundTofacitinib (Tofa) has been approved for moderately to severely active ulcerative colitis (UC). To improve its therapeutic efficacy and limit dose-dependent toxicity, we developed a macromolecular prodrug of Tofa (P-Tofa). If the prodrug design improves… read more here.
Keywords: tofa; prodrug; ulcerative colitis; mice ... See more keywords
Different effects of acetyl-CoA carboxylase inhibitor TOFA on airway inflammation and airway resistance in a mice model of asthma
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DOI: 10.1007/s43440-019-00027-8
Abstract: Background and objective Acetyl CoA carboxylase (ACC) regulates the differentiation of Th1, Th2, Th17 cells and Treg cells, which play a critical role in airway inflammation of asthma. Here we investigated the role of ACC… read more here.
Keywords: tofa; airway inflammation; expression; acetyl coa ... See more keywords
THU0185 THE FIRST REPORT OF SIGNIFICANTLY IMPROVEMENT OF NT-PROBNP LEVEL IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH TOFACITINIB DURING 12-MONTH FOLLOW-UP
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.2865
Abstract: Background The amino-terminal fragment of the B-type natriuretic peptide prohormone (NT-proBNP) is a marker for functional cardiac impairment and is increased in heart disease with or without symptoms of congestive heart failure (CHF)1. Objectives To… read more here.
Keywords: none declared; tofa; probnp level;
POS0448 DISCONTINUATION RATE OF TOFACITINIB AS MONOTHERAPY IS SIMILAR COMPARED TO COMBINATION THERAPY WITH METHOTREXATE IN RHEUMATOID ARTHRITIS PATIENTS: POOLED DATA FROM TWO RHEUMATOID ARTHRITIS REGISTRIES IN CANADA
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DOI: 10.1136/annrheumdis-2021-eular.920
Abstract: Tofacitinib (TOFA) is an oral, small molecule drug used for rheumatoid arthritis (RA) treatment and is prescribed alone or with methotrexate (MTX). We previously reported the similarity in retention between TOFA monotherapy and TOFA with… read more here.
Keywords: mtx; arthritis; discontinuation; rheumatoid arthritis ... See more keywords
Tofacitinib Ameliorates Lipopolysaccharide-Induced Acute Kidney Injury by Blocking the JAK-STAT1/STAT3 Signaling Pathway
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DOI: 10.1155/2021/8877056
Abstract: Septic acute kidney injury (AKI) is the most common AKI syndrome in the intensive care unit (ICU), and it accounts for approximately half of AKI cases. Tofacitinib (TOFA) is a pan-Janus kinase (JAK) inhibitor that… read more here.
Keywords: jak; kidney injury; tofa; aki ... See more keywords