Synthesis of CF3-containing oxazolines via trifluoromethylation of allylamides with Togni reagent in the presence of alkali metal iodides
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.07.012
Abstract: Abstract We report an efficient synthetic method for CF 3 -containing oxazolines via trifluoromethylation of allylamides by using Togni reagent in the presence of alkali metal iodides, which play a key role in selective production… read more here.
Keywords: via trifluoromethylation; togni reagent; containing oxazolines; trifluoromethylation allylamides ... See more keywords
Copper-Catalyzed Reductive Trifluoromethylation of Alkyl Iodides with Togni's Reagent.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02005
Abstract: This work illustrates a reductive cross-electrophile coupling protocol for trifluoromethylation of alkyl iodides under Cu-catalyzed/Ni-promoted reaction conditions. The use of diboron esters as the terminal reductant allows the effective generation of the alkyl-CF3 products with… read more here.
Keywords: alkyl; alkyl iodides; togni reagent; trifluoromethylation alkyl ... See more keywords
Metal-Free Construction of the C(sp3)-CF3 Bond: Trifluoromethylation of Hydrazones with Togni's Reagent under Mild Conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02072
Abstract: A metal-free trifluoromethylation of hydrazones with Togni's reagent under mild conditions was developed. Various functional groups including ester, methoxy, dimethoxy, nitro, halogen, and heterocyclic compounds were tolerated. This simple and green strategy provides a practical… read more here.
Keywords: mild conditions; togni reagent; trifluoromethylation hydrazones; metal free ... See more keywords
An efficient metal-free desulfurization strategy promoted by Togni-II reagent.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00983a
Abstract: Desulfurization is a versatile synthetic tool in organic synthesis, particularly in peptide chemistry, where it offers an effective conversion strategy for compounds that contain mercaptan groups. In this study, we present a metal-free desulfurization method… read more here.
Keywords: togni reagent; metal free; desulfurization; strategy ... See more keywords