Outer Membrane Channel Protein TolC Regulates Escherichia coli K12 Sensitivity to Plantaricin BM-1 via the CpxR/CpxA Two-Component Regulatory System
Sign Up to like & getrecommendations! Published in 2020 at "Probiotics and Antimicrobial Proteins"
DOI: 10.1007/s12602-020-09671-6
Abstract: Plantaricin BM-1, a class IIa bacteriocin produced by Lactobacillus plantarum BM-1, has significant antibacterial activity against Gram-positive and Gram-negative bacteria. This study aimed to explore the role of the Escherichia coli K12 outer membrane (OM)… read more here.
Keywords: k12; coli k12; escherichia coli; plantaricin ... See more keywords
In silico epitope identification of unique multidrug resistance proteins from Salmonella Typhi for vaccine development
Sign Up to like & getrecommendations! Published in 2019 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2018.11.020
Abstract: Typhoid fever is a multisystemic illness caused by Salmonella enterica serovars Typhi and is resistant to most antibiotics and drugs. The resistance is conferred through multidrug resistance (MDR) proteins, which efflux most antibiotics and other… read more here.
Keywords: mdr proteins; tolc; cell epitopes; multidrug resistance ... See more keywords
Structural Features and Energetics of the Periplasmic Entrance Opening of the Outer Membrane Channel TolC Revealed by Molecular Dynamics Simulation and Markov State Model Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00957
Abstract: TolC is a channel protein responsible for substrate translocation across the outer membrane, and it is also a part of the tripartite multidrug efflux pumps in Gram-negative bacteria. The crystal structure of TolC shows that… read more here.
Keywords: markov state; periplasmic entrance; outer membrane; tolc ... See more keywords
Resveratrol controls Escherichia coli growth by inhibiting the AcrAB‐TolC efflux pump
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DOI: 10.1093/femsle/fnz030
Abstract: &NA; Resveratrol (RSV), a phytoalexin found in grapes and other plants, is known to have antibacterial effects against Escherichia coli. In this study, we aimed to identify the target gene(s) for the antibacterial activity of… read more here.
Keywords: pump; rsv; tolc; acrab tolc ... See more keywords
A comprehensive description of the TolC effect on the antimicrobial susceptibility profile in Enterobacter bugandensis
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DOI: 10.3389/fcimb.2022.1036933
Abstract: Background Enterobacter bugandensis is an emerging human pathogen in which multidrug resistant strains have been continuously isolated from various environments. Thus, this organism possesses the potential to pose challenges in human healthcare. However, the mechanisms,… read more here.
Keywords: susceptibility; cmcc 45301; tolc; enterobacter bugandensis ... See more keywords
Effects of TolC on the pathogenicity of porcine extraintestinal pathogenic Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.929740
Abstract: Extraintestinal pathogenic Escherichia coli (ExPEC) is a well-known critical pathogenic zoonosis that causes extraintestinal infections in humans and animals by affecting their immune organs. Recently, research on the outer membrane protein of E. coli, tolerant… read more here.
Keywords: escherichia coli; extraintestinal pathogenic; tolc; pathogenic escherichia ... See more keywords
Crucial Role of Legionella pneumophila TolC in the Inhibition of Cellular Trafficking in the Protistan Host Paramecium tetraurelia
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00800
Abstract: Legionella pneumophila is a facultative intracellular Gram-negative bacterium, which is a major causative agent of Legionnaires’ disease. In the environment, this bacterium survives in free-living protists such as amoebae and Tetrahymena. The association of L.… read more here.
Keywords: paramecium; legionella pneumophila; pneumophila; tolc ... See more keywords
Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00166
Abstract: TolC and the other members of the outer membrane factor (OMF) family are outer membrane proteins forming trimeric channels that serve as a conduit for most actively effluxed substrates in Gram-negative bacteria by providing a… read more here.
Keywords: alpha barrel; pump; tolc; domain ... See more keywords