Inhibition of adaptive therapy tolerance in cancer: is triplet mitochondrial targeting the key?
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13406
Abstract: Targeted therapies have become a mainstay in the treatment of cancer, but their long‐term efficacy is compromised by acquired drug resistance. Acquired therapy resistance develops via two phases—first through adaptive development of nongenetic drug tolerance,… read more here.
Keywords: therapy tolerance; triplet; tolerance; drug ... See more keywords
Calculation of delivered composite dose from Calypso tracking data for prostate cancer: And subsequent evaluation of reasonable treatment interruption tolerance limits
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12684
Abstract: Abstract Purpose In this study we calculate composite dose delivered to the prostate by using the Calypso tracking ‐data‐ stream acquired during patient treatment in our clinic. We evaluate the composite distributions under multiple simulated… read more here.
Keywords: prostate; composite dose; tolerance; tracking data ... See more keywords
Using a daily monitoring system to reduce treatment position override rates in external beam radiation therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13629
Abstract: Abstract Purpose/objectives: To report our 7‐year experience with a daily monitoring system to significantly reduce couch position overrides and errors in patient treatment positioning. Materials and methods: Treatment couch position override data were extracted from… read more here.
Keywords: tolerance; monitoring system; treatment; daily monitoring ... See more keywords
Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune Tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202238
Abstract: During autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing debilitating inflammation for millions of patients. There is no cure for most of these diseases. Further, available therapies modulate inflammation… read more here.
Keywords: immune tolerance; tolerance; drug delivery; antigen specific ... See more keywords
Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205105
Abstract: Autoimmunity and allergies affect a large number of people across the globe. Current approaches to these diseases target cell types and pathways that drive disease, but these approaches are not cures and cannot differentiate between… read more here.
Keywords: immune tolerance; strategies selective; biomaterial strategies; selective immune ... See more keywords
Photosynthetic heat tolerance in plants with different foliar water -uptake strategies.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of botany"
DOI: 10.1002/ajb2.1648
Abstract: PREMISE The distribution and even the survival of plant species are influenced by temperature. In an old climatically buffered infertile landscape (OCBIL) in Brazil, we previously characterized different strategies for foliar water uptake (FWU). It… read more here.
Keywords: tolerance; water; foliar water; water absorption ... See more keywords
When males have females on their backs: Male's tolerance, solicitation, and use of female–male mounting in Japanese macaques
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Primatology"
DOI: 10.1002/ajp.23395
Abstract: Previous research on Japanese macaques has shown that female‐to‐male mounting (FMM) is performed by some females as an exaggerated form of sexual solicitation that may occur in the context of high female competition for male… read more here.
Keywords: male; fmm; female male; tolerance ... See more keywords
Introducing sorghum DREB2 gene in maize (Zea mays L.) to improve drought and salinity tolerance.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2458
Abstract: Salinity and drought are significant abiotic stresses causing a considerable loss of seed and biomass yield in most commercial crops. Some of the most critical players in the ABA pathway are Drought Response Element Binding… read more here.
Keywords: dreb2 gene; dreb2; tolerance; salinity ... See more keywords
Overexpression of OLE1 enhances stress tolerance and constitutively activates the MAPK HOG pathway in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26093
Abstract: OLE1 of Saccharomyces cerevisiae encodes the sole and essential Δ‐9 desaturase catalyzing the conversion of saturated to unsaturated fatty acids. Upon ectopic overexpression of OLE1 in S. cerevisiae, significant increases in the membrane oleic acid… read more here.
Keywords: ole1; overexpression; hog pathway; saccharomyces cerevisiae ... See more keywords
Chromosomal mutations in Escherichia coli that improve tolerance to nonvolatile side‐products from dilute acid treatment of sugarcane bagasse
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27189
Abstract: Lignocellulosic biomass provides attractive nonfood carbohydrates for the production of ethanol, and dilute acid pretreatment is a biomass‐independent process for access to these carbohydrates. However, this pretreatment also releases volatile and nonvolatile inhibitors of fermenting… read more here.
Keywords: tolerance; escherichia coli; tolerance nonvolatile; dilute acid ... See more keywords
Recent advances in yeast genome evolution with stress tolerance for green biological manufacturing
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28183
Abstract: Green biological manufacturing is a revolutionary industrial model utilizing yeast as a significant microbial cell factory to produce biofuels and other biochemicals. However, biotransformation efficiency is often limited owing to several stress factors resulting from… read more here.
Keywords: stress; tolerance; genome evolution; biological manufacturing ... See more keywords