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   Articles with "tolerance" as a keyword



Inhibition of adaptive therapy tolerance in cancer: is triplet mitochondrial targeting the key?

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recommendations! Published in 2023 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13406

Abstract: Targeted therapies have become a mainstay in the treatment of cancer, but their long‐term efficacy is compromised by acquired drug resistance. Acquired therapy resistance develops via two phases—first through adaptive development of nongenetic drug tolerance,… read more here.

Keywords: therapy tolerance; triplet; tolerance; drug ... See more keywords

Calculation of delivered composite dose from Calypso tracking data for prostate cancer: And subsequent evaluation of reasonable treatment interruption tolerance limits

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recommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.12684

Abstract: Abstract Purpose In this study we calculate composite dose delivered to the prostate by using the Calypso tracking ‐data‐ stream acquired during patient treatment in our clinic. We evaluate the composite distributions under multiple simulated… read more here.

Keywords: prostate; composite dose; tolerance; tracking data ... See more keywords

Using a daily monitoring system to reduce treatment position override rates in external beam radiation therapy

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recommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.13629

Abstract: Abstract Purpose/objectives: To report our 7‐year experience with a daily monitoring system to significantly reduce couch position overrides and errors in patient treatment positioning. Materials and methods: Treatment couch position override data were extracted from… read more here.

Keywords: tolerance; monitoring system; treatment; daily monitoring ... See more keywords

Low Loss Chip‐to‐Chip Couplers for High‐Density Co‐Packaged Optics

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recommendations! Published in 2024 at "Advanced Engineering Materials"

DOI: 10.1002/adem.202402095

Abstract: An experimentally demonstrated, vertical chip‐to‐chip evanescent coupler between silicon nitride (SiN x$_{x}$ ) and silicon (Si) is presented with the coupler loss measured to be 0.39  ±$\pm$  1.06 dB at 1550 nm with a 1‐dB bandwidth of… read more here.

Keywords: loss; chip chip; tolerance; optics ... See more keywords

Lattice Hydrogen Boosts CO Tolerance of Pd Anode Catalysts in High‐Temperature Proton Exchange Membrane Fuel Cells

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202415358

Abstract: High‐temperature proton exchange membrane fuel cells (HT‐PEMFCs) demonstrate crude hydrogen can be a cost‐effective fuel source. However, the performance of HT‐PEMFCs is hindered by challenges such as high‐concentration CO poisoning and preferential adsorption of H3PO4… read more here.

Keywords: temperature proton; fuel; tolerance; high temperature ... See more keywords

Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune Tolerance

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recommendations! Published in 2022 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202202238

Abstract: During autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing debilitating inflammation for millions of patients. There is no cure for most of these diseases. Further, available therapies modulate inflammation… read more here.

Keywords: immune tolerance; tolerance; drug delivery; antigen specific ... See more keywords

Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202205105

Abstract: Autoimmunity and allergies affect a large number of people across the globe. Current approaches to these diseases target cell types and pathways that drive disease, but these approaches are not cures and cannot differentiate between… read more here.

Keywords: immune tolerance; strategies selective; biomaterial strategies; selective immune ... See more keywords

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507740

Abstract: Enhancing microbial tolerance to target chemicals through conventional adaptive laboratory evolution (ALE) is time‐consuming, labor‐intensive, and further constrained by the challenge of balancing improved tolerance with maintaining optimal biosynthetic efficiency. Here, this work proposes a… read more here.

Keywords: laboratory evolution; efficiency; tolerance; adaptive laboratory ... See more keywords

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202511570

Abstract: Globally, soil salinization increasingly affects farmland, severely limiting the production of Tartary buckwheat (Fagopyrum tataricum). To identify genetic factors for salt tolerance, we analyzed core Tartary buckwheat accessions and utilized differential expression analysis and genome-wide association… read more here.

Keywords: tartary buckwheat; magnesium transporter; salt tolerance; tolerance ... See more keywords

Dynamic Defect Tolerance in Metal Halide Perovskites: From Phenomena to Mechanism

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recommendations! Published in 2025 at "Advanced Energy Materials"

DOI: 10.1002/aenm.202405239

Abstract: Metal halide perovskite‐based devices can exhibit exceptional optoelectronic performance at relatively high defect densities, a phenomenon commonly referred to as defect tolerance, which is one of the most important features of metal halide perovskites (MHPs).… read more here.

Keywords: tolerance; halide perovskites; dynamic defect; metal halide ... See more keywords

Structure‐based engineering of O‐succinyl‐L‐homoserine mercaptotransferase with improved substrate tolerance

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recommendations! Published in 2025 at "AIChE Journal"

DOI: 10.1002/aic.70059

Abstract: O‐Succinyl‐L‐homoserine mercaptotransferase (MetZ) is a key enzyme for the synthesis of L‐methionine. However, the limited tolerance to high concentrations of substrate methyl mercaptan sodium restricts its industrial applications, while the “trade‐off” between activity and stability… read more here.

Keywords: succinyl homoserine; engineering; homoserine mercaptotransferase; tolerance ... See more keywords