S-adenosyl methionine (SAM) attenuates the development of tolerance to analgesic activity of morphine in rats
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DOI: 10.1016/j.neulet.2017.02.054
Abstract: BACKGROUND Development of tolerance to analgesic effect, on chronic administration of morphine, limits its clinical usefulness in pain management. S-adenosyl methionine (SAM) used for arthritis and approved as a supplement in many countries including United… read more here.
Keywords: tolerance; morphine; tolerance analgesic; sam ... See more keywords