Tolerance and dependence following chronic alprazolam treatment in rhesus monkeys: Role of GABAA receptor subtypes.
Sign Up to like & getrecommendations! Published in 2021 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2021.108985
Abstract: BACKGROUND To assess GABAA receptor subtypes involved in benzodiazepine tolerance and dependence, we evaluated the ability of subtype-selective and non-selective ligands to substitute for (i.e., produce "cross-tolerance") or precipitate withdrawal during chronic alprazolam treatment. METHODS… read more here.
Keywords: gabaa receptor; tolerance; chronic alprazolam; receptor subtypes ... See more keywords
AMPA receptor positive allosteric modulators attenuate morphine tolerance and dependence
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.04.020
Abstract: &NA; Development of opioid tolerance and dependence hinders the use of opioids for the treatment of chronic pain. In searching for the mechanism and potential intervention for opioid tolerance and dependence, we studied the action… read more here.
Keywords: dependence; tolerance; positive allosteric; tolerance dependence ... See more keywords
Effects of glucosamine against morphine-induced antinociceptive tolerance and dependence in mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-019-0513-1
Abstract: BackgroundThe most important limitations of morphine in pain therapy are its tolerance and dependence. In this study, we evaluated the protective effect of glucosamine against morphine-induced tolerance and dependence in mice.MethodsMice received twice daily morphine… read more here.
Keywords: morphine; tolerance; effect; glucosamine ... See more keywords
The effect of metformin on morphine analgesic tolerance and dependence in rats
Sign Up to like & getrecommendations! Published in 2018 at "Research in Pharmaceutical Sciences"
DOI: 10.4103/1735-5362.235158
Abstract: Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of… read more here.
Keywords: morphine; tolerance; dependence rats; analgesic tolerance ... See more keywords