Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective
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DOI: 10.1002/sctm.16-0358
Abstract: Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades,… read more here.
Keywords: mechanisms tolerance; medicine; tolerance; hematopoietic chimerism ... See more keywords
Tolerance Induction of Horse Allergy by Horse Contact with Curly Horses.
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DOI: 10.1055/s-0043-108137
Abstract: A horse allergic rider completed 60 riding lessons on Curly Horses within six months. This rider has become clinically tolerant to normal horse breeds within this time. This case may indicate that riding and brushing… read more here.
Keywords: curly horses; horse; induction horse; horse allergy ... See more keywords
One More Step Toward a Clinically Applicable Tolerance Induction Protocol in Solid Organ Transplantation?
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DOI: 10.1097/tp.0000000000001712
Abstract: A broadly applicable protocol for tolerance induction in solid organ transplantation is still to be found. In this issue of Transplantation, Xie et al report a novel strategy that appears to be both safe and… read more here.
Keywords: protocol; organ transplantation; transplantation; tolerance induction ... See more keywords
Unraveling the Crucial Roles of FoxP3+ Regulatory T Cells in Vascularized Composite Allograft Tolerance Induction and Maintenance.
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DOI: 10.1097/tp.0000000000003509
Abstract: BACKGROUND The role of regulatory T cells (Treg) in tolerance induction of vascularized composite allotransplantation (VCA) remains unclear. This study was designed to examine characteristics of Treg after VCA, and their capacity to rescue allografts… read more here.
Keywords: tolerance; treg; rejection; regulatory cells ... See more keywords
Chimerism-based Tolerance Induction in Clinical Transplantation: Its Foundations and Mechanisms.
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DOI: 10.1097/tp.0000000000004589
Abstract: Hematopoietic chimerism remains the most promising strategy to bring transplantation tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the recipient's mechanisms of self-tolerance (ie, clonal deletion, anergy, and regulation) to include… read more here.
Keywords: chimerism; based tolerance; transplantation; tolerance ... See more keywords
The effects of brain death and ischemia on tolerance induction are organ‐specific
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14674
Abstract: We have previously shown that 12 days of high‐dose calcineurin inhibition induced tolerance in MHC inbred miniature swine receiving MHC‐mismatched lung, kidney, or co‐transplanted heart/kidney allografts. However, if lung grafts were procured from donation after… read more here.
Keywords: tolerance induction; brain; brain death; kidney ... See more keywords
Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors—A retrospective analysis
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DOI: 10.1111/hae.13413
Abstract: Immune tolerance induction (ITI) is the gold standard for eradication of factor VIII inhibitors in severe haemophilia A; however, it usually requires treatment for extended periods with associated high burden on patients and healthcare resources. read more here.
Keywords: tolerance induction; immune tolerance; factor viii; severe haemophilia ... See more keywords
Immune tolerance induction: What have we learned over time?
Sign Up to like & getrecommendations! Published in 2018 at "Haemophilia"
DOI: 10.1111/hae.13445
Abstract: Development of inhibitory antibodies to infused factor VIII (FVIII) concentrates continues to be the most serious complication of haemophilia A management. Induction of immune tolerance by administering high doses of FVIII concentrate (antigen) and prothrombin… read more here.
Keywords: iti therapy; immune tolerance; tolerance induction; induction ... See more keywords
Evaluation of anti‐factor VIII antibody levels in patients with haemophilia A receiving immune tolerance induction therapy or bypassing agents
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DOI: 10.1111/hae.14202
Abstract: Bleeding episodes in patients who have haemophilia A (HA), a hereditary bleeding disorder caused by a deficiency in factor VIII (FVIII), are treated or prophylactically prevented with infusions of exogenous FVIII. Neutralizing antibodies, referred to… read more here.
Keywords: patients haemophilia; immune tolerance; factor viii; induction therapy ... See more keywords
Nephrotic syndrome in two haemophilia B children with inhibitor under low‐dose immune tolerance induction combined with rituximab‐based immunosuppressant protocol
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DOI: 10.1111/hae.14471
Abstract: Patientswith haemophilia B (HB)may develop factor IX (FIX) inhibitors with a cumulative incidence of 10.2% following FIX replacement therapy by 500 exposure days.1 In 50–60% cases, occurrence of severe allergic reactions may precede or occur… read more here.
Keywords: dose iti; nephrotic syndrome; low dose; dose ... See more keywords
Eradication of FIX inhibitor in haemophilia B children using low‐dose immune tolerance induction with rituximab‐based immunosuppressive agent(s) in China
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DOI: 10.1111/hae.14577
Abstract: Development of haemophilia B inhibitors (HBI) results in the ineffectiveness of FIX replacement therapy. Inhibitor eradication by immune tolerance induction (ITI) is therefore necessary. In HBI, ITI even at high FIX dose is less effective… read more here.
Keywords: immune tolerance; inhibitor; haemophilia; eradication ... See more keywords