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   Articles with "tolerance induction" as a keyword



Mechanisms of Tolerance Induction by Hematopoietic Chimerism: The Immune Perspective

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recommendations! Published in 2017 at "Stem Cells Translational Medicine"

DOI: 10.1002/sctm.16-0358

Abstract: Hematopoietic chimerism is one of the effective approaches to induce tolerance to donor‐derived tissue and organ grafts without administration of life‐long immunosuppressive therapy. Although experimental efforts to develop such regimens have been ongoing for decades,… read more here.

Keywords: mechanisms tolerance; medicine; tolerance; hematopoietic chimerism ... See more keywords

Advances in Immune Tolerance Induction in Enzyme Replacement Therapy

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recommendations! Published in 2024 at "Paediatric Drugs"

DOI: 10.1007/s40272-024-00627-9

Abstract: Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a metabolic/biochemical pathway or other disturbances in the metabolic pathway including transport… read more here.

Keywords: enzyme replacement; therapy; replacement therapy; tolerance induction ... See more keywords
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Tolerance Induction of Horse Allergy by Horse Contact with Curly Horses.

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recommendations! Published in 2017 at "Pneumologie"

DOI: 10.1055/s-0043-108137

Abstract: A horse allergic rider completed 60 riding lessons on Curly Horses within six months. This rider has become clinically tolerant to normal horse breeds within this time. This case may indicate that riding and brushing… read more here.

Keywords: curly horses; horse; induction horse; horse allergy ... See more keywords

The current state of tolerance induction in vascularized composite allotransplantation

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recommendations! Published in 2024 at "Current Opinion in Organ Transplantation"

DOI: 10.1097/mot.0000000000001176

Abstract: Purpose of review Significant advancements have been made in the field of vascularized composite allotransplantation (VCA); however, like solid organ transplantation, bypassing the recipient's immune response remains a significant obstacle to long-term allograft survival. Therefore,… read more here.

Keywords: tolerance; tolerance induction; vascularized composite; composite allotransplantation ... See more keywords
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One More Step Toward a Clinically Applicable Tolerance Induction Protocol in Solid Organ Transplantation?

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recommendations! Published in 2017 at "Transplantation"

DOI: 10.1097/tp.0000000000001712

Abstract: A broadly applicable protocol for tolerance induction in solid organ transplantation is still to be found. In this issue of Transplantation, Xie et al report a novel strategy that appears to be both safe and… read more here.

Keywords: protocol; organ transplantation; transplantation; tolerance induction ... See more keywords

Unraveling the Crucial Roles of FoxP3+ Regulatory T Cells in Vascularized Composite Allograft Tolerance Induction and Maintenance.

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recommendations! Published in 2020 at "Transplantation"

DOI: 10.1097/tp.0000000000003509

Abstract: BACKGROUND The role of regulatory T cells (Treg) in tolerance induction of vascularized composite allotransplantation (VCA) remains unclear. This study was designed to examine characteristics of Treg after VCA, and their capacity to rescue allografts… read more here.

Keywords: tolerance; treg; rejection; regulatory cells ... See more keywords

Chimerism-based Tolerance Induction in Clinical Transplantation: Its Foundations and Mechanisms.

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recommendations! Published in 2023 at "Transplantation"

DOI: 10.1097/tp.0000000000004589

Abstract: Hematopoietic chimerism remains the most promising strategy to bring transplantation tolerance into clinical routine. The concept of chimerism-based tolerance aims to extend the recipient's mechanisms of self-tolerance (ie, clonal deletion, anergy, and regulation) to include… read more here.

Keywords: chimerism; based tolerance; transplantation; tolerance ... See more keywords

The effects of brain death and ischemia on tolerance induction are organ‐specific

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recommendations! Published in 2018 at "American Journal of Transplantation"

DOI: 10.1111/ajt.14674

Abstract: We have previously shown that 12 days of high‐dose calcineurin inhibition induced tolerance in MHC inbred miniature swine receiving MHC‐mismatched lung, kidney, or co‐transplanted heart/kidney allografts. However, if lung grafts were procured from donation after… read more here.

Keywords: tolerance induction; brain; brain death; kidney ... See more keywords

Recombinant factor VIII Fc fusion protein for immune tolerance induction in patients with severe haemophilia A with inhibitors—A retrospective analysis

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recommendations! Published in 2018 at "Haemophilia"

DOI: 10.1111/hae.13413

Abstract: Immune tolerance induction (ITI) is the gold standard for eradication of factor VIII inhibitors in severe haemophilia A; however, it usually requires treatment for extended periods with associated high burden on patients and healthcare resources. read more here.

Keywords: tolerance induction; immune tolerance; factor viii; severe haemophilia ... See more keywords
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Immune tolerance induction: What have we learned over time?

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recommendations! Published in 2018 at "Haemophilia"

DOI: 10.1111/hae.13445

Abstract: Development of inhibitory antibodies to infused factor VIII (FVIII) concentrates continues to be the most serious complication of haemophilia A management. Induction of immune tolerance by administering high doses of FVIII concentrate (antigen) and prothrombin… read more here.

Keywords: iti therapy; immune tolerance; tolerance induction; induction ... See more keywords

Evaluation of anti‐factor VIII antibody levels in patients with haemophilia A receiving immune tolerance induction therapy or bypassing agents

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recommendations! Published in 2020 at "Haemophilia"

DOI: 10.1111/hae.14202

Abstract: Bleeding episodes in patients who have haemophilia A (HA), a hereditary bleeding disorder caused by a deficiency in factor VIII (FVIII), are treated or prophylactically prevented with infusions of exogenous FVIII. Neutralizing antibodies, referred to… read more here.

Keywords: patients haemophilia; immune tolerance; factor viii; induction therapy ... See more keywords