Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.
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DOI: 10.1016/j.jaut.2018.01.005
Abstract: Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)+ DCs can delay but not completely block diabetes development… read more here.
Keywords: tregs; islet; tolerance via; cd25 ... See more keywords