GPX4 Inhibition Selectively Targets Drug-Tolerant Persister Cells.
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DOI: 10.1158/2159-8290.cd-rw2017-215
Abstract: Targeting GPX4 induces selective cell death of drug-tolerant persister tumor cells by ferroptosis. read more here.
Keywords: drug tolerant; gpx4 inhibition; tolerant persister; inhibition selectively ... See more keywords
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy
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DOI: 10.15252/emmm.202114903
Abstract: Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we identified the acquisition of a DTP phenotype in multidrug‐resistant (MDR)… read more here.
Keywords: drug tolerant; dtp state; tolerant persister; cancer ... See more keywords
Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer
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DOI: 10.3390/cancers13112666
Abstract: Simple Summary Acquired resistance to molecularly targeted therapies remains a major challenge in the treatment of cancer. It has been hypothesized that drug-tolerant (or “persister”) cells without bona fide resistance mechanisms may survive initial drug… read more here.
Keywords: persister cells; drug; resistance; cancer ... See more keywords