Bayesian optimization for estimating the maximum tolerated dose in Phase I clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2021.100753
Abstract: We introduce a Bayesian optimization method for estimating the maximum tolerated dose in this article. A number of parametric model-based methods have been proposed to estimate the maximum tolerated dose; however, parametric model-based methods need… read more here.
Keywords: tolerated dose; bayesian optimization; method; maximum tolerated ... See more keywords
Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0735-y
Abstract: Rambaldi, A., Iurlo, A., Vannucchi, A. M., Noble, R., von Bubnoff, N., Guarini, A., Martino, B., Pezzutto, A., Carli, G., De Muro, M., Luciani, S., McMullin, M. F., Cambier, N., Marolleau, J-P., Mesa, R. A.,… read more here.
Keywords: efficacy maximum; tolerated dose; safety efficacy; givinostat polycythemia ... See more keywords