Role of the Abcg2 transporter in plasma levels and tissue accumulation of the anti-inflammatory tolfenamic acid in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2021.109537
Abstract: The Breast Cancer Resistance Protein (BCRP/ABCG2) is an ATP-binding cassette efflux transporter that is expressed in the apical membrane of cells from relevant tissues involved in drug pharmacokinetics such as liver, intestine, kidney, testis, brain… read more here.
Keywords: plasma; acid; tolfenamic acid; mice ... See more keywords
Synthesis, characterization, antioxidant and antidiabetic studies of Cu(II) and Zn(II) complexes of tolfenamic acid/mefenamic acid with 1-methylimidazole
Sign Up to like & getrecommendations! Published in 2020 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2020.119942
Abstract: Abstract Cu(II) and Zn(II) complexes of tolfenamic acid (tolf) and mefenamic acid (mef) with 1-methylimidazole (1-mdz) formulated as [Cu(tolf)2(1-mdz)2] (1) [Cu(mef)2(1-mdz)2]·H2O (2) and [Zn2(tolf)4(1-mdz)2] (3) were synthesized and characterized by elemental analysis, spectroscopic techniques and… read more here.
Keywords: mefenamic acid; complexes tolfenamic; geometry; tolfenamic acid ... See more keywords
Tolfenamic acid on-line preconcentration strategy on carbon nanotubes minicolumn with fluorimetric detection.
Sign Up to like & getrecommendations! Published in 2020 at "Talanta"
DOI: 10.1016/j.talanta.2019.120345
Abstract: Nonsteroidal anti-inflammatory agents (NSAIDs) are a group of pharmaceuticals considered one of the most popular drugs used in clinical practice applied to the treatment of acute and chronic conditions. Some pharmaceuticals products are excreted reaching… read more here.
Keywords: line preconcentration; methodology; carbon nanotubes; tolfenamic acid ... See more keywords
Pharmacokinetics of tolfenamic acid in red-eared slider turtles (Trachemys scripta elegans).
Sign Up to like & getrecommendations! Published in 2019 at "Veterinary anaesthesia and analgesia"
DOI: 10.1016/j.vaa.2019.05.009
Abstract: OBJECTIVE To determine the pharmacokinetics of tolfenamic acid (TA) after different routes of administration [intravenous (IV) and intramuscular (IM), 2 mg kg-1] and doses (IV, 2 and 4 mg kg-1) in red-eared slider turtles (Trachemys… read more here.
Keywords: tolfenamic acid; red eared; eared slider; slider turtles ... See more keywords
Synergistic effect of tolfenamic acid and glycyrrhizic acid on TPA-induced skin inflammation in mice.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00345b
Abstract: Tolfenamic acid (TA) and glycyrrhizic acid (GA) are well-known components with anti-inflammatory properties. However, their combined effects on inflammation have not been well studied. The present study aimed to investigate the in vivo anti-inflammatory effects… read more here.
Keywords: tolfenamic acid; acid glycyrrhizic; tpa induced; inflammation ... See more keywords
Combination use of tolfenamic acid with curcumin improves anti-inflammatory activity and reduces toxicity in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.13240
Abstract: Long-term use of tolfenamic acid inevitably causes side effects, including gastric ulcer and hepatotoxicity. Curcumin is generally recognized to be anti-inflammatory, hepatoprotective, and gastroprotective. Herein, we investigated the combinational effects of tolfenamic acid and curcumin… read more here.
Keywords: anti inflammatory; tolfenamic acid; use tolfenamic; acid curcumin ... See more keywords
Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep.
Sign Up to like & getrecommendations! Published in 2020 at "Acta veterinaria Hungarica"
DOI: 10.1556/004.2020.00015
Abstract: The pharmacokinetics of levofloxacin (4 mg/kg), administered both alone and in combination with tolfenamic acid (2 mg/kg) and flunixin meglumine (2.2 mg/kg), was established after intravenous administration in sheep. Plasma levofloxacin concentrations were assayed by… read more here.
Keywords: acid flunixin; flunixin meglumine; tolfenamic acid;
Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy.
Sign Up to like & getrecommendations! Published in 2018 at "Current Alzheimer research"
DOI: 10.2174/1567205015666180119104036
Abstract: BACKGROUND Tangles are deposits of hyperphosphorylated tau, which are found in multiple neurodegenerative disorders that are referred to as tauopathies, of which Alzheimer's disease (AD) is the most common. Tauopathies are clinically characterized by dementia… read more here.
Keywords: protein; tau; tolfenamic acid; tau protein ... See more keywords