Tollip‐deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide
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DOI: 10.1002/2211-5463.13423
Abstract: Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein aggregates and various signaling processes in mammalian models. To verify evolutionary conservation of these functions, we used CRISPR/Cas9 editing to construct… read more here.
Keywords: tollip deficient; display; development; gene expression ... See more keywords
Gamma irradiation enhanced Tollip‐mediated anti‐inflammatory action through structural modification of quercetin in lipopolysaccharide‐stimulated macrophages
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DOI: 10.1016/j.intimp.2016.11.030
Abstract: Abstract The changes in molecular structure and anti‐inflammatory action of a gamma‐irradiated quercetin were examined. Quercetin was gamma‐irradiated at doses of 0, 15, 30, 50, 100 and 150 kGy, which induced new radiolytic peaks (the… read more here.
Keywords: gamma irradiated; irradiated quercetin; tollip; action ... See more keywords
Tollip Inhibits IL-33 Release and Inflammation in Influenza A Virus-Infected Mouse Airways.
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DOI: 10.1159/000525315
Abstract: Respiratory influenza A virus (IAV) infection continues to pose significant challenges in healthcare of human diseases including asthma. IAV infection in mice was shown to increase IL-33, a key cytokine in driving airway inflammation in… read more here.
Keywords: inflammation; release; iav infection; influenza virus ... See more keywords
PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
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DOI: 10.3389/fimmu.2022.731500
Abstract: Pleckstrin homology-like domain, family A, member 1 (PHLDA1) has been reported to be expressed in many mammalian tissues and cells. However, the functions and exact mechanisms of PHLDA1 remain unclear. In this study, we found… read more here.
Keywords: proinflammatory cytokine; phlda1; production; cytokine production ... See more keywords
TOLLIP Protein Expression Predicts Unfavorable Outcome in Renal Cell Carcinoma
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DOI: 10.3390/ijms232314702
Abstract: Resistance to systemic therapy is one of the hallmarks of renal cell carcinoma (RCC). Recently, TOLLIP has emerged as a possible driver of autophagy and chemoresistance. We explored the relationship between primary and metastatic RCC… read more here.
Keywords: cell carcinoma; renal cell; expression; tollip ... See more keywords