Design, synthesis of celecoxib-tolmetin drug hybrids as selective and potent COX-2 inhibitors.
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DOI: 10.1016/j.bioorg.2019.103029
Abstract: Three novel series of diarylpyrazole 10b-d and triarylpyrazole derivatives 11a-d &12a-d were synthesized through Vilsmier-Haack condition. The structures of prepared compounds were determined through IR, 1H NMR, 13C NMR, Mass spectral and elemental analysis. Docking… read more here.
Keywords: design synthesis; celecoxib; celecoxib tolmetin; tolmetin drug ... See more keywords