Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.01.003
Abstract: Mitochondria import nearly all of their resident proteins from the cytosol, and the TOM complex functions as their entry gate. The TOM complex undergoes a dynamic conversion between the majority population of a three-channel gateway… read more here.
Keywords: porin associates; tom22 regulate; associates tom22; tom complex ... See more keywords
Beyond ER: Regulating TOM-Complex-Mediated Import by Ubx2.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.07.003
Abstract: Despite the progress in understanding the molecular responses to mitochondrial damage, responses to aberrant accumulation of mitochondrial precursor proteins and mitochondrial import defects remain poorly understood. Recent work (Mårtensson et al., Nature, 2019) has unveiled… read more here.
Keywords: beyond regulating; import; complex mediated; tom complex ... See more keywords
Dynamic Coupling between Tom22 Motions and Tom40 Pore Dynamics Modulates Ion Transport in the Mitochondrial TOM Complex
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.5c01761
Abstract: Mitochondria rely on the efficient import of proteins to maintain their functions and regenerate. The translocase of the outer mitochondrial membrane (TOM) complex serves as the primary entry point for the import of mitochondrial proteins.… read more here.
Keywords: tom; coupling tom22; dynamic coupling; tom complex ... See more keywords
Structure of an ex vivoDrosophila TOM complex determined by single-particle cryoEM
Sign Up to like & getrecommendations! Published in 2025 at "IUCrJ"
DOI: 10.1107/s2052252524011011
Abstract: A 3.3 Å resolution map and structural model of the TOM complex from Drosophila melanogaster were determined by single-particle cryoEM. The complex was extracted from native membranes of the fly retina following targeted expression of a… read more here.
Keywords: determined single; single particle; tom complex; particle cryoem ... See more keywords
Role of the TOM Complex in Protein Import into Mitochondria: Structural Views.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-032620-104527
Abstract: Mitochondria are central to energy production, metabolism and signaling, and apoptosis. To make new mitochondria from preexisting mitochondria, the cell needs to import mitochondrial proteins from the cytosol into the mitochondria with the aid of… read more here.
Keywords: tom complex; import; role tom; tom ... See more keywords
Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3000098
Abstract: Mitochondria originated from proteobacterial endosymbionts, and their transition to organelles was tightly linked to establishment of the protein import pathways. The initial import of most proteins is mediated by the translocase of the outer membrane… read more here.
Keywords: tom complex; tom; triplet pore; protein ... See more keywords
The TOM complex from an evolutionary perspective and the functions of TOMM70
Sign Up to like & getrecommendations! Published in 2024 at "Biological Chemistry"
DOI: 10.1515/hsz-2024-0043
Abstract: Abstract In humans, up to 1,500 mitochondrial precursor proteins are synthesized at cytosolic ribosomes and must be imported into the organelle. This is not only essential for mitochondrial but also for many cytosolic functions. The… read more here.
Keywords: tom; evolutionary perspective; functions tomm70; tom complex ... See more keywords