Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1917743117
Abstract: We described a reduction of target of Myb1 (TOM1) protein levels by Western blot in the postmortem hippocampus of subjects with Alzheimer’s disease (AD) versus nondemented subjects (1), validating similar findings by an independent research… read more here.
Keywords: protein; tom1; alzheimer disease; disease ... See more keywords
Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.643769
Abstract: Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions.… read more here.
Keywords: protein; tom1; protein trafficking; cargo sorting ... See more keywords