The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108936
Abstract: Most mitochondrial proteins are synthesized as precursors in the cytosol and post-translationally transported into mitochondria. The mitochondrial surface protein Tom70 acts at the interface of the cytosol and mitochondria. In vitro import experiments identified Tom70 as… read more here.
Keywords: tom70; mitochondrial surface; receptor; chaperone binding ... See more keywords
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Immunology"
DOI: 10.1038/s41423-020-0514-8
Abstract: COVID-19 is caused by SARS-CoV-2. As of July 16th, 2020, there were 13,579,581 diagnosed cases and 584,782 deaths attributed to COVID-19 reported globally (https://coronavirus.jhu.edu/map. html). Unfortunately, there is still no effective drug or vaccine for… read more here.
Keywords: tom70; ifn; fig; interaction ... See more keywords
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.75658
Abstract: Mitochondrial biogenesis has two major steps: the transcriptional activation of nuclear genome-encoded mitochondrial proteins and the import of nascent mitochondrial proteins that are synthesized in the cytosol. These nascent mitochondrial proteins are aggregation-prone and can… read more here.
Keywords: mitochondrial biogenesis; biogenesis aging; mitochondrial proteins; nascent mitochondrial ... See more keywords