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   Articles with "tomm40" as a keyword



Association and interaction of TOMM40 and PVRL2 with plasma amyloid-β and Alzheimer's disease among Chinese older adults: a population-based study

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recommendations! Published in 2022 at "Neurobiology of aging"

DOI: 10.1016/j.neurobiolaging.2021.12.013

Abstract: Genetic studies have identified Alzheimer's disease (AD)-associated SNPs in TOMM40 and PVRL2 genes, but the underlying mechanisms remain unknown. We examined their associations and interactions with AD risk and plasma biomarkers among Chinese older adults.… read more here.

Keywords: tomm40 pvrl2; pvrl2; tomm40; among chinese ... See more keywords
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APOE ɛ4 allele and TOMM40‐APOC1 variants jointly contribute to survival to older ages

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recommendations! Published in 2022 at "Aging Cell"

DOI: 10.1111/acel.13730

Abstract: Age‐related diseases characteristic of post‐reproductive life, aging, and life span are the examples of polygenic non‐Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their risks independently or… read more here.

Keywords: survival older; tomm40; carriers minor; older ages ... See more keywords
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Longer TOMM40 poly-T variants associated with higher FDDNP-PET medial temporal tau and amyloid binding

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0208358

Abstract: Background The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with the apolipoprotein E (APOE) gene, has been implicated in Alzheimer’s disease (AD). TOMM40 influences AD pathology through mitochondrial neurotoxicity, and… read more here.

Keywords: tomm40 poly; fddnp; tomm40; binding ... See more keywords
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MicroRNA-22-3p Restrains the Proliferation, Phenotypic Transformation, and Migration of Vascular Smooth Muscle Cells by Manipulating TOMM40.

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recommendations! Published in 2022 at "International heart journal"

DOI: 10.1536/ihj.21-829

Abstract: microRNA (miR) -22-3p has been confirmed to be engaged in the phenotype transformation and proliferation of vascular smooth muscle cells (VSMCs), which is intimately correlated with restenosis. The current research set out to explore the… read more here.

Keywords: tomm40; proliferation; smooth muscle; migration ... See more keywords