Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of aging"
DOI: 10.1016/j.neurobiolaging.2021.09.009
Abstract: Despite advances, the roles of genetic variants from the APOE-harboring 19q13.32 region in Alzheimer's disease (AD) remain controversial. We leverage a comprehensive approach to gain insights into a more homogeneous genetic architecture of AD in… read more here.
Keywords: apoc1 variants; apoe apoc1; definitive roles; tomm40 apoe ... See more keywords
DNA methylation of TOMM40-APOE-APOC2 in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Human Genetics"
DOI: 10.1038/s10038-017-0393-8
Abstract: The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for Alzheimer’s disease (AD). Multiple regulatory elements, spanning the extended TOMM40-APOE-APOC2 region, regulate gene expression at this locus. Regulatory element DNA methylation changes… read more here.
Keywords: apoe apoc2; methylation; tomm40 apoe; region ... See more keywords
Long-Lived Individuals Show a Lower Burden of Variants Predisposing to Age-Related Diseases and a Higher Polygenic Longevity Score
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810949
Abstract: Longevity is a complex phenotype influenced by both environmental and genetic factors. The genetic contribution is estimated at about 25%. Despite extensive research efforts, only a few longevity genes have been validated across populations. Long-lived… read more here.
Keywords: lived individuals; longevity; age related; tomm40 apoe ... See more keywords