Long‐term open‐label perampanel: Generalized tonic–clonic seizures in idiopathic generalized epilepsy
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DOI: 10.1002/epi4.12602
Abstract: Assess the longer‐term efficacy and safety of adjunctive perampanel (up to 12 mg/day) in patients aged ≥12 years with generalized tonic–clonic (GTC) seizures from the Open‐label Extension (OLEx) Phase of Study 332 to determine whether responses obtained… read more here.
Keywords: long term; generalized tonic; term; tonic clonic ... See more keywords
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice
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DOI: 10.1007/s11064-020-03175-z
Abstract: Protective (antiseizure) effects of 4-butyl-5-[(4-chloro-2-methylphenoxy)-methyl]-2,4-dihydro-3 H -1,2,4-triazole-3-thione (TPL-16) and acute neurotoxic effects were determined in the tonic-clonic seizure model and rotarod test in mice. The interaction profile of four classic antiepileptic drugs (carbamazepine, phenobarbital, phenytoin… read more here.
Keywords: tpl; tonic clonic; phenobarbital phenytoin; carbamazepine phenobarbital ... See more keywords
Anticonvulsant drugs for generalized tonic-clonic epilepsy
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DOI: 10.1080/14656566.2017.1328499
Abstract: ABSTRACT Introduction: Primary generalized tonic clonic seizures (pGTCS) are still linked to major concerns for the clinic and hazards for patients suffering from idiopathic generalized epilepsy (IGE), so a quick search of the most effective… read more here.
Keywords: epilepsy; tonic clonic; first choice; valproic acid ... See more keywords
Open‐label study to investigate the safety and efficacy of adjunctive perampanel in pediatric patients (4 to
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsia"
DOI: 10.1111/epi.16413
Abstract: Study 311 (NCT02849626) was a global, multicenter, open‐label, single‐arm study that assessed safety, tolerability, pharmacokinetics, and pharmacokinetics/pharmacodynamics of once‐daily adjunctive perampanel oral suspension in pediatric patients (aged 4 to read more here.
Keywords: adjunctive perampanel; tonic clonic; study; clonic seizures ... See more keywords
Predictors of focal to bilateral tonic‐clonic seizures during long‐term video‐EEG monitoring
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DOI: 10.1111/epi.16454
Abstract: To determine predictors of focal to bilateral tonic‐clonic seizures (FBTCS) during video–electroencephalography (EEG) monitoring (VEM). read more here.
Keywords: tonic clonic; predictors focal; eeg monitoring; clonic seizures ... See more keywords
Focal to bilateral tonic–clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
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DOI: 10.1111/epi.16819
Abstract: Our objective was to identify whether the whole‐brain structural network alterations in patients with temporal lobe epilepsy (TLE) and focal to bilateral tonic–clonic seizures (FBTCS) differ from alterations in patients without FBTCS. read more here.
Keywords: lobe epilepsy; tonic clonic; clonic seizures; temporal lobe ... See more keywords
Risk of Recurrence in Patients with an Unprovoked Tonic-Clonic Seizure and Generalized Epileptiform Discharges on EEG.
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DOI: 10.1111/epi.17671
Abstract: OBJECTIVE The decision to initiate treatment in patients with a first unprovoked seizure remains controversial. Studies have reported a recurrence rate ranging from 21-50%, but most have included patients with different etiologies, EEG findings, and… read more here.
Keywords: seizure; recurrence patients; recurrence; risk recurrence ... See more keywords
Reverse Takotsubo cardiomyopathy associated with tonic clonic seizure: a rare form of Takotsubo cardiomyopathy
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DOI: 10.1136/bcr-2021-246703
Abstract: A woman in her 30s presented with generalised tonic clonic seizure secondary to known pilocytic astrocytoma. This seizure activity resolved spontaneously after 5 min. On clinical assessment, she was neurologically stable and further neurological investigations did… read more here.
Keywords: clonic seizure; takotsubo cardiomyopathy; tonic clonic; takotsubo ... See more keywords
Forgetting to take antiseizure medications is associated with focal to bilateral tonic-clonic seizures, as revealed by a cross-sectional study
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DOI: 10.1371/journal.pone.0240082
Abstract: Objectives To evaluate the effects of nonadherence to antiseizure medications (ASMs) and clinical characteristics on seizure control, we employed a prospective cohort cross-sectional study using self-reports and medical records of patients with epilepsy (PWEs). Methods… read more here.
Keywords: tonic clonic; antiseizure medications; forgetting take; bilateral tonic ... See more keywords
Dynamic Susceptibility Contrast Enhanced (DSC) MRI Perfusion and Plasma Cytokine Levels in Patients after Tonic-clonic Seizures
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DOI: 10.1515/raon-2017-0031
Abstract: Abstract Background Inflammatory events in brain parenchyma and glial tissue are involved in epileptogenesis. Blood concentration of cytokines is shown to be elevated after tonic-clonic seizures. As a result of inflammation, blood-brain barrier leakage occurs.… read more here.
Keywords: perfusion; tonic clonic; mri perfusion; clonic seizures ... See more keywords
Bilateral Quadriceps Tendon Rupture and Femoral Neck Fracture After Generalized Tonic-Clonic Seizures
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DOI: 10.2106/jbjs.cc.20.00062
Abstract: Case: We report on a 19-year-old male renal transplant patient with multiple medical issues who sustained simultaneous bilateral quadriceps tendon ruptures and bilateral femoral neck fractures after 2 generalized tonic-clonic seizures. The quadriceps tendon ruptures… read more here.
Keywords: femoral neck; clonic seizures; tonic clonic; quadriceps tendon ... See more keywords