Tonic dopamine, uncertainty and basal ganglia action selection
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.05.010
Abstract: To make optimal decisions in uncertain circumstances flexible adaption of behaviour is required; exploring alternatives when the best choice is unknown, exploiting what is known when that is best. Using a computational model of the… read more here.
Keywords: model; action selection; tonic dopamine;
Second-Derivative-Based Background Drift Removal for a Tonic Dopamine Measurement in Fast-Scan Cyclic Voltammetry.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01047
Abstract: The dysregulation of dopamine, a neuromodulator, is associated with a broad spectrum of brain disorders, including Parkinson's disease, addiction, and schizophrenia. Quantitative measurements of dopamine are essential for understanding dopamine functional dynamics. Fast-scan cyclic voltammetry… read more here.
Keywords: background drift; cyclic voltammetry; dopamine; scan cyclic ... See more keywords
Continuous long-range measurement of tonic dopamine with advanced FSCV for pharmacodynamic analysis of levodopa-induced dyskinesia in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2024.1335474
Abstract: Levodopa, a dopamine prodrug, alleviates the motor symptoms of Parkinson’s disease (PD), but its chronic use gives rise to levodopa-induced dyskinesia (LID). However, it remains unclear whether levodopa pharmacodynamics is altered during the progressive onset… read more here.
Keywords: dopamine; tonic dopamine; levodopa induced; induced dyskinesia ... See more keywords
High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1061578
Abstract: Cocaine’s addictive properties stem from its capacity to increase tonic extracellular dopamine levels in the nucleus accumbens (NAc). The ventral tegmental area (VTA) is a principal source of NAc dopamine. To investigate how high frequency… read more here.
Keywords: cocaine administration; dopamine; dopamine levels; tonic dopamine ... See more keywords