Activity- and sleep-dependent regulation of tonic inhibition by Shisa7
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.108899
Abstract: SUMMARY Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABAARs) critically regulates neuronal excitability and brain function. However, the mechanisms regulating tonic inhibition remain poorly understood. Here, we report that Shisa7 is critical… read more here.
Keywords: tonic inhibition; regulation tonic; inhibition; dependent regulation ... See more keywords
Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-39729-7
Abstract: Spontaneous excitability and contractions of colonic smooth muscle cells (SMCs) are normally suppressed by inputs from inhibitory motor neurons, a behavior known as tonic inhibition. The post-junctional cell(s) mediating tonic inhibition have not been elucidated.… read more here.
Keywords: suppression ca2; inhibition; tonic inhibition; proximal colon ... See more keywords
Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor δ-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells
Sign Up to like & getrecommendations! Published in 2019 at "eNeuro"
DOI: 10.1523/eneuro.0364-18.2019
Abstract: Abstract Copy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP)… read more here.
Keywords: expression; tonic inhibition; gabaa receptor; inhibition dentate ... See more keywords
Activity-Dependent Modulation of Tonic GABA Currents by Endocannabinoids in Hirudo verbana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.760330
Abstract: Endocannabinoids are lipid neuromodulators that are synthesized on demand and primarily signal in a retrograde manner to elicit depression of excitatory and inhibitory synapses. Despite the considerable interest in their potential analgesic effects, there is… read more here.
Keywords: activity dependent; tonic inhibition; inhibition; modulation tonic ... See more keywords
Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.822499
Abstract: Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse model of… read more here.
Keywords: tonic inhibition; inhibition; astrocyte; gaba ... See more keywords
Unaltered Tonic Inhibition in the Arcuate Nucleus of Diet-induced Obese Mice
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurobiology"
DOI: 10.5607/en22014
Abstract: The principal inhibitory transmitter, γ-aminobutyric acid (GABA), is critical for maintaining hypothalamic homeostasis and released from neurons phasically, as well as from astrocytes tonically. Although astrocytes in the arcuate nucleus (ARC) of the hypothalamus are… read more here.
Keywords: tonic inhibition; inhibition; obese mice; unaltered tonic ... See more keywords