Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion.
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DOI: 10.1073/pnas.2219086120
Abstract: Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or… read more here.
Keywords: cell; tregs; exhaustion; tonic signaling ... See more keywords