Novel genetic tools for probing individual H3 molecules in each nucleosome
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0910-0
Abstract: In eukaryotes, genomic DNA is packaged into the nucleus together with histone proteins, forming chromatin. The fundamental repeating unit of chromatin is the nucleosome, a naturally symmetric structure that wraps DNA and is the substrate… read more here.
Keywords: individual molecules; novel genetic; genetic tools; molecules nucleosome ... See more keywords
Chemical biology tools for probing transcytosis at the blood–brain barrier† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc04024b
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c9sc04024b
Abstract: A BBB vehicle library is validated, establishing a SAR for uptake. Merging AMT/RMT motifs chemoselectively increased permeability. read more here.
Keywords: chemical biology; biology tools; chemical; biology ... See more keywords
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0083
Abstract: Sirtuins are NAD+-dependent protein deacylases capable of cleaving off acetyl as well as other acyl groups from the ɛ-amino group of lysines in histones and other substrate proteins. They have been reported as promising drug… read more here.
Keywords: nad dependent; new chemical; chemical tools; lysine ... See more keywords